护理点测试国际标准化比率:它们对监测血栓中心的维生素K拮抗剂有用吗?

D. Barcellona, L. Fenu, F. Marongiu
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引用次数: 0

摘要

护理点检测(POCT)国际归一化比率(INR)装置被广泛接受用于维生素K拮抗剂(vka)的自我检测和自我管理。这项工作的目的是评估POCT在我们血栓中心的性能,旨在减少患者用于血液采样和剂量调整的时间。共有101例连续口服抗凝患者(53例M, 48例F,中位年龄74岁,23-89岁)纳入研究,研究分为2个不同的阶段。第一阶段进行3个月的标准监测;在此期间,还通过毛细管血液样本测定INR值,并使用POCT比较两种系统获得的INR值。在第二阶段,仅使用CoaguChek XS Plus对患者进行3个月的监测。Bland-Altman试验表明,自动凝血仪和CoaguChek XS Plus获得的INR值吻合良好。通过和Bablok检验显示线性无显著偏差。在标准监测和使用CoaguChek XS Plus期间,总中位等待时间分别为3小时45分钟(0:44至6:05)和1小时16分钟(P < 0.001)。CoaguChek XS Plus是一种适合在血栓中心监测VKA治疗的POCT,从而大大减少了患者采血和等待剂量调整的时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Points of Care Testing International Normalized Ratio: Are They Useful for Monitoring Vitamin K Antagonists in a Thrombosis Center?
Abstract Point of care testing (POCT) international normalized ratio (INR) devices are widely accepted for self-testing and self-management of vitamin K antagonists (VKAs). The aim of this work was to evaluate the performance of a POCT at our thrombosis centre aiming at reducing the time spent by patients for blood sampling and dose adjustment. A total of 101 consecutive oral anticoagulated patients (53 M, 48 F, median age 74 years, 23–89) were enrolled in the study that consisted of 2 different phases. In the first, standard monitoring was carried out for 3 months; during this period, the INR value was also determined by capillary blood sample with the use of a POCT to compare the INR values obtained with the two systems. In the second phase, patients were monitored for 3 months using only the CoaguChek XS Plus. The Bland-Altman test showed a good agreement between INR values obtained with the automated coagulometer and the CoaguChek XS Plus. The Passing and Bablok test showed no significant deviation from linearity. The total median waiting time was 3 hours and 45 minutes (from 0:44 to 6:05) and 1 hour and 16 minutes (P < 0.001) during standard monitoring and the use of the CoaguChek XS Plus, respectively. CoaguChek XS Plus is a suitable POCT for monitoring VKA therapy at a thrombosis centre, thus significantly reducing the time spent by patients for blood sampling and waiting for dosage adjustment.
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