时间生物学和昼夜节律在2型糖尿病中的作用:对糖尿病管理的影响

T. Kurose, Takanori Hyo, D. Yabe, Y. Seino
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引用次数: 11

摘要

生物钟调节着所有生物体的细胞到有机和个体的行为水平。动物体内几乎所有的细胞都有受环境信号影响的自我维持的时钟。基因研究的最新进展包括确定生物钟基因,这些基因的破坏会导致代谢异常,如糖尿病、肥胖和高脂血症。在这里,我们回顾了最近关于昼夜节律紊乱、轮班工作、饮食行为改变和睡眠-觉醒周期紊乱的研究进展,并参考了2型糖尿病的管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes
Circadian clocks regulate cellular to organic and individual behavior levels of all organisms. Almost all cells in animals have self-sustained clocks entrained by environmental signals. Recent progress in genetic research has included identification of clock genes whose disruption causes metabolic abnormalities such as diabetes, obesity, and hyperlipidemia. Here we review recent advances in research on circadian disruption, shift work, altered eating behaviors, and disrupted sleep-wake cycles, with reference to management of type 2 diabetes.
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