一种新型亲心性丙二酸衍生物的有效性和安全性的实验评价

Journal Biomed Pub Date : 2022-10-18 DOI:10.33647/2074-5982-18-3-109-112

D. Ivkin, A. A. Karpov

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引用次数: 0

摘要

4-[(3-乙氧基-3-氧丙基)氨基]苯甲酸(etmaben)具有致心作用的临床前研究进行了一整个周期。研究了其潜在的作用机制和药理作用、急性和慢性实验中的一般毒性作用、特定毒性类型(致敏性、免疫毒性、生殖毒性、致突变性)和药代动力学。该药物被发现具有明显的心性作用和积极的安全性，这证明了开展I期临床试验的理由。

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Experimental Evaluation of the Effectiveness and Safety of a New Propandic Acid Derivative Exhibiting Cardiotropic Action

An entire cycle of preclinical studies of 4-[(3-ethoxy-3-oxopropanoyl)amino]benzoic acid (etmaben) exhibiting cardiotropic action was carried out. Its potential action mechanism and pharmacological effects, general toxic effects in acute and chronic experiments, specific types of toxicity (allergenicity, immunotoxicity, reproductive toxicity, mutagenicity), and pharmacokinetics were studied. The drug was found to have a pronounced cardiotropic effect and a positive safety profile, which justifies the launch of phase I clinical trials.

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Journal Biomed

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