{"title":"美托沙坦对睾丸组织影响的研究进展","authors":"Eswari Beeram, Suman Bukke, Divya Bysani","doi":"10.36648/2248-9215.9.3.87","DOIUrl":null,"url":null,"abstract":"Metosartan induces so many deleterious effects in male Wistar rats treated with drug and RNase. It causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm count. It induces the x-chromosome desynapsis leading to testicular carcinoma. The effects are so profound in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis in testicular tissue mainly through intrinsic pathway which is mainly due to genotoxic agents. The drug mainly inhibits RNase A in rat testes and has positive effect on Mitosis.","PeriodicalId":12012,"journal":{"name":"European Journal of Experimental Biology","volume":"13 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Review on Effects of Metosartan on Testes Tissue\",\"authors\":\"Eswari Beeram, Suman Bukke, Divya Bysani\",\"doi\":\"10.36648/2248-9215.9.3.87\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Metosartan induces so many deleterious effects in male Wistar rats treated with drug and RNase. It causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm count. It induces the x-chromosome desynapsis leading to testicular carcinoma. The effects are so profound in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis in testicular tissue mainly through intrinsic pathway which is mainly due to genotoxic agents. The drug mainly inhibits RNase A in rat testes and has positive effect on Mitosis.\",\"PeriodicalId\":12012,\"journal\":{\"name\":\"European Journal of Experimental Biology\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Experimental Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36648/2248-9215.9.3.87\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Experimental Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36648/2248-9215.9.3.87","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metosartan induces so many deleterious effects in male Wistar rats treated with drug and RNase. It causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm count. It induces the x-chromosome desynapsis leading to testicular carcinoma. The effects are so profound in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis in testicular tissue mainly through intrinsic pathway which is mainly due to genotoxic agents. The drug mainly inhibits RNase A in rat testes and has positive effect on Mitosis.
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