Stress/inflammation and pai-1 as stellar processes in the aging and associated pathologies

Decades ago Hans Hugo Bruno Selye expressed the concept of stress as a pathophysiological syndrome generated by various endogenous / exogenous harmful agents and named it as the "General Adaptation Syndrome". This concept implicitly involves a complex process of damage and specific or non-specific defence of the organism that accompanies us throughout life, especially in the aging process and the diseases associated, whose symptoms are independent of the nature of the harmful agent, representing a response to the damage as such [1-3].