口腔病变中亲银核仁组织区(Agnors)的预后潜力:一项系统综述

Shafali Singh, D. Bhargava, Sheeba Ali, Richa Mishra, V. Chandavarkar
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引用次数: 0

摘要

口腔鳞状细胞癌(OSCC)和口腔潜在恶性疾病(OPMD)的早期检测对牙科专业人员提高患者生存率非常重要。超过一半的口腔鳞状细胞癌患者在诊断时病情已经进展,这表明缺乏早期发现和风险评估的生物标志物。新的蛋白质生物标志物的开发将有助于早期诊断和治疗。亲银核仁组织者区(AgNORs)染色技术简单,成本效益高。这些是识别上皮发育不良的复制标记。它在鉴别口腔的良性、癌前和恶性病变方面也起着非常重要的作用。每个细胞的AgNORs数量被认为是细胞增殖活性的一个指标。显微镜下,NORs可以被识别为分布在细胞核中的定义明确的黑点。agNOR的数量与细胞的增殖活性严格成正比。AgNOR定量有助于确定上皮异常增生的程度,从而分析其恶性转化的可能性。AgNOR的定性特征有助于鉴别增生性、癌前病变和恶性口腔病变。银染色技术可用于研究核仁的结构及其活性的变化。AgNORs在肿瘤病理学中是一个有价值的参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic Potential of Argyrophillic Nucleolar Organizer Regions (Agnors) in Oral Lesions: A Systematic Review
Early detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is important for dental professionals to improve patient survival rates. More than half of patients with oral squamous cell cancer had advanced disease at the time of diagnosis, indicating a lack of early detection and risk assessment biomarkers. The development of new protein biomarkers will help in early diagnosis and treatment.The argyrophilic nucleolar organiser regions (AgNORs) staining technique is simple and cost-effective. These are replicatory markers that identify epithelial dysplasia. And it also plays a very important role in differentiating the benign, pre-malignant, and malignant lesions of the oral cavity. The number of AgNORs per cell has been considered an indicator of cellular proliferative activity. Microscopically, NORs can be identified as well-defined black dots located throughout the cell nucleus. The agNOR quantity is strictly proportional to the proliferative activity of the cell. AgNOR quantification helps in the determination of the degree of epithelial dysplasia and, consequently, in the analysis of its potential for malignant transformation. AgNOR qualitative characteristics help in differentiating hyperplastic, premalignant, and malignant oral lesions. The sliver staining technique is useful for studying the structure of the nucleolus as well as the variations in its activity. AgNORs are a valuable parameter in tumour pathology.
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