Metronomic Chemotherapy in Selected Children with Refractory Tumors; Report of Four Cases and a Review of the Literature

Metronomic chemotherapy is the continual, systemic administration of non-toxic chemotherapy doses that target proliferating endothelial cells during tumor angiogenesis [1]. This strategy began 40 years ago in adult oncology, but there is few experiences in pediatric settings [2]. After a systematic review on evidence-based documents and selection of metronomic chemotherapy protocols from the literature; eligible patients were received this kind of chemotherapy after informed consent taken from their parents.