动脉平滑肌中的基本钙信号

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Channels Pub Date : 2019-01-01 DOI:10.1080/19336950.2019.1688910

Gang Fan, Yingqiu Cui, M. Gollasch, M. Kassmann

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引用次数: 22

摘要

外周小动脉血管平滑肌细胞(VSMCs)通过调节其收缩状态参与血压控制。这些适应依赖于VSMC细胞质Ca2+浓度，由复杂的局部基本Ca2+信号通路调节。钙离子火花代表局部的，短暂的，快速的钙释放事件从肌浆网的一群红嘌呤受体(RyRs)。在动脉SMCs中，Ca2+火花激活附近的钙依赖性钾通道，引起膜超极化，从而降低整体细胞内[Ca2+]以对抗血管收缩。动脉SMC Cav1.2 l型通道调节细胞内钙储存含量，进而调节钙通过RyRs外排。在某些类型的动脉中，Cav3.2 t型通道有助于少量扩展Ca2+火花的产生。它们在细胞膜小泡内的定位至关重要。我们总结了动脉SMCs中局部基本钙信号(Ca2+火花)的现有数据，重点关注RyR亚型，大电导钙依赖性钾(BKCa)通道和细胞膜结合钙通道(Cav1.2和Cav3.2)，特别是在腔泡微域。

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Elementary calcium signaling in arterial smooth muscle

ABSTRACT Vascular smooth muscle cells (VSMCs) of small peripheral arteries contribute to blood pressure control by adapting their contractile state. These adaptations depend on the VSMC cytosolic Ca2+ concentration, regulated by complex local elementary Ca2+ signaling pathways. Ca2+ sparks represent local, transient, rapid calcium release events from a cluster of ryanodine receptors (RyRs) in the sarcoplasmic reticulum. In arterial SMCs, Ca2+ sparks activate nearby calcium-dependent potassium channels, cause membrane hyperpolarization and thus decrease the global intracellular [Ca2+] to oppose vasoconstriction. Arterial SMC Cav1.2 L-type channels regulate intracellular calcium stores content, which in turn modulates calcium efflux through RyRs. Cav3.2 T-type channels contribute to a minor extend to Ca2+ spark generation in certain types of arteries. Their localization within cell membrane caveolae is essential. We summarize present data on local elementary calcium signaling (Ca2+ sparks) in arterial SMCs with focus on RyR isoforms, large-conductance calcium-dependent potassium (BKCa) channels, and cell membrane-bound calcium channels (Cav1.2 and Cav3.2), particularly in caveolar microdomains.

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来源期刊

Channels 生物-生化与分子生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.