M. Cunha, T. P. A. Filho, F. A. Cunha, Ana Gesselena da Silva Farias, I. P. Souza, E. A. Menezes
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In vitro synergistic activity of lidocaine and miconazole against Candida albicans
Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.
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