紫外线B辐射及其对雌性Wistar大鼠甲状腺危害的初步研究

IF 0.4 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

International Journal of Radiation Research Pub Date : 2022-04-01 DOI:10.52547/ijrr.20.2.36

G. Rai, P. Mahobiya

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引用次数: 0

摘要

背景:本研究旨在探讨紫外线B (UVB)辐射对雌性Wistar大鼠甲状腺的影响。材料与方法:12 ~ 16周龄、体重130 ~ 150gm的雌性大鼠24只，饲养在标准笼中，饲喂无菌食物和水，供随意饮用。动物被分成四组。ⅰ组为对照组，ⅰ组暴露于280 nm UVB辐射下2 h/d。第三组以280 nm UVB照射2 h/d，口服姜黄素25 mg/kg体重。第四组患者给予姜黄素25 mg/kg体重口服。所有治疗持续15天。结果:UVB辐射使大鼠体和甲状腺重量下降。但同时升高T3、T4、FT3、FT4水平(p<0.01: p<0.001;p<0.05)，显著降低TSH水平(p<0.001)。组织学上，UVB辐射对卵泡细胞损伤，胶体液消失，卵泡直径明显减小(p<0.01)。结论:UVB辐射引起雌性Wistar大鼠甲状腺激素失衡，诱发甲状腺功能亢进，姜黄素对UVB辐射对甲状腺功能亢进有保护作用。

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Eventual study of ultraviolet B radiation and their peril on thyroid gland of female Wistar rat

Background : The present study was carried out to estimate the effect of Ultraviolet B (UVB) radiation on the thyroid gland of female Wistar rats. Materials and Methods : Female rat (n=24) of 12-16 weeks with body weight of 130-150gm were housed in standard cages, fed sterilized food and water ad libitum. Animals were divided into four groups. Ist group was control, IInd group was exposed to 280 nm of UVB radiation for 2 h/day. IIIrd group was exposed to 280 nm of UVB radiation for 2 h/day and 25 mg/kg body weight curcumin orally. IVth group was given 25 mg/kg body weight curcumin orally. All treatments last for 15 days. Results : The results showed that UVB radiation decreased body and thyroid gland weight. However at the same time increased T3, T4, FT3, and FT4 levels (p<0.01: p<0.001; p<0.05) and decreased the level of TSH (p<0.001) significantly. Histologically, UVB radiation-damaged follicular cells and disappeared colloid fluid, and decreased follicle diameter significantly (p<0.01). Conclusion : It is concluded that UVB radiation generates imbalance in thyroid hormones and induced hyperthyroidism on female Wistar rat and curcumin play protective role in hyperthyroidism against UVB radiation.

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来源期刊

International Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.10

自引率

33.30%

发文量

期刊介绍： International Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.