疟疾快速诊断测试(RDTs)

E. Obeagu, U. Chijioke, Ifeoma Stella Ekelozie
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引用次数: 13

摘要

疟疾是一种热带和亚热带地区的疾病,由受感染的雌性按蚊传播。疟疾是挑战世界这一地区的主要传染病之一。这导致每年的生命损失,特别是儿童和母亲。使用实验室方法已成为必要,因为卫生工作者无法仅凭临床体征和症状可靠地确定疟疾病例。通常,血液涂片的光学显微镜是检测疟疾寄生虫的参考金标准,也是实验室确认疟疾的既定方法。如果技术熟练和细心的科学家使用,它甚至可以在每μl血液5-10个寄生虫的低密度下检测出疟疾寄生虫。然而,基于显微镜的疟疾诊断是劳动密集型和耗时的。世卫组织建议使用快速诊断检测,以加强对已宣布治疗并发症的病例预防的诊断和管理,延长生存期并监测治疗情况,特别是对儿童。为了获得更高的敏感性和特异性,应该对RDTs进行更多的研究。卫生工作者,特别是医学实验室科学家和临床医生不应忽视显微镜检查,这是诊断疟疾的金标准。生命是宝贵的,应该小心对待。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Malaria Rapid Diagnostic Test (RDTs)
Malaria is a disease of the tropics and sub-tropics which is transmitted by infected female Anopheles mosquito. Malaria is one of the major infections challenging this part of the world. This leads to loss of lives every year especially children and mothers. The use of laboratory methods has become necessary because health workers cannot identify malaria cases reliably using clinical signs and symptoms alone. Conventionally, light microscopy of a blood smear is the reference gold standard for the detection of malaria parasites and the established method for the laboratory confirmation of malaria. It can detect malaria parasites even at low densities of 5-10 parasites/μl of blood when used by skilled and careful scientist. However, malaria diagnosis based on microscopy is labour intensive and time-consuming. Rapid diagnostic tests (RDTs) are recommended by WHO to enhance diagnosis and management of case prevention of complications of declared treatment, prolonging survival and monitoring of treatment especially in children. More research should be done in RDTs for higher sensitivity and specificity. Health workers especially medical laboratory scientist and clinicians should not neglect microscopy which is the gold standard for the diagnosis of malaria. Life is precious and should be carefully handled.
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