{"title":"山茱萸的抗溃疡作用。水果抗大鼠胃溃疡。","authors":"I. Kuppast, P. Nayak, K. C. Prakash, K. Kumar","doi":"10.5580/14b9","DOIUrl":null,"url":null,"abstract":"The anti-ulcer effect of extracts of Cordia dichotoma Forst.f. fruits (300mg/kg body weight) was studied in albino rats of Wistar strain using three different models i.e. pyloric ligation, aspirin and indomethacin induced ulcers. The extractions of C.dichotoma Forst.f. fruits were carried out using ethanol. This extract was fractionated using petroleum ether, solvent ether, ethyl acetate, butanol and butanone in succession. Gastric mucosal injury was produced in rats by pyloric ligation, aspirin and indomethacin induced models. Extracts of petroleum ether, solvent ether, ethyl acetate, butanol and butanone were administered in a dose of 300 mg/kg body weight. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicates that, extracts of ethyl acetate, butanol and butanone significantly (p< 0.001) decrease the volume of gastric secretion, free acidity, total acidity and ulcer index with respect to control. The results suggest that the extracts of Cordia dichotoma Forst.f. fruits possess significant anti-ulcer activity.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"11 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Anti-ulcer effect of Cordia dichotoma Forst .f. fruits against gastric ulcers in rats.\",\"authors\":\"I. Kuppast, P. Nayak, K. C. Prakash, K. Kumar\",\"doi\":\"10.5580/14b9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The anti-ulcer effect of extracts of Cordia dichotoma Forst.f. fruits (300mg/kg body weight) was studied in albino rats of Wistar strain using three different models i.e. pyloric ligation, aspirin and indomethacin induced ulcers. The extractions of C.dichotoma Forst.f. fruits were carried out using ethanol. This extract was fractionated using petroleum ether, solvent ether, ethyl acetate, butanol and butanone in succession. Gastric mucosal injury was produced in rats by pyloric ligation, aspirin and indomethacin induced models. Extracts of petroleum ether, solvent ether, ethyl acetate, butanol and butanone were administered in a dose of 300 mg/kg body weight. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicates that, extracts of ethyl acetate, butanol and butanone significantly (p< 0.001) decrease the volume of gastric secretion, free acidity, total acidity and ulcer index with respect to control. The results suggest that the extracts of Cordia dichotoma Forst.f. fruits possess significant anti-ulcer activity.\",\"PeriodicalId\":22523,\"journal\":{\"name\":\"The Internet Journal of Pharmacology\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/14b9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/14b9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-ulcer effect of Cordia dichotoma Forst .f. fruits against gastric ulcers in rats.
The anti-ulcer effect of extracts of Cordia dichotoma Forst.f. fruits (300mg/kg body weight) was studied in albino rats of Wistar strain using three different models i.e. pyloric ligation, aspirin and indomethacin induced ulcers. The extractions of C.dichotoma Forst.f. fruits were carried out using ethanol. This extract was fractionated using petroleum ether, solvent ether, ethyl acetate, butanol and butanone in succession. Gastric mucosal injury was produced in rats by pyloric ligation, aspirin and indomethacin induced models. Extracts of petroleum ether, solvent ether, ethyl acetate, butanol and butanone were administered in a dose of 300 mg/kg body weight. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicates that, extracts of ethyl acetate, butanol and butanone significantly (p< 0.001) decrease the volume of gastric secretion, free acidity, total acidity and ulcer index with respect to control. The results suggest that the extracts of Cordia dichotoma Forst.f. fruits possess significant anti-ulcer activity.
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