移民工人在孟加拉国的HIV-1毒株多样性中起着关键作用

IF 0.3 Q4 INFECTIOUS DISEASES
Md. Safiullah Sarker, T. Azim, L. Islam, Mustafizur Rahman
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引用次数: 2

摘要

孟加拉国是人类免疫缺陷病毒(HIV)低流行国,基因分型数据有限,不完整,主要是基于gag基因的C亚型。在本文中,我们对来自孟加拉国不同地理区域的三个HIV检测和咨询(HTC)中心的个体获得的HIV-1株进行了基于三个基因的综合表征。材料和方法:从2005-2007年在HTC中心就诊的个人中获得了40份具有人口统计学和移民史的hiv阳性血液标本。从全血中提取DNA,并使用HIV基因组gag, pol和env区域特异性引物进行测序。结果:以C亚型为主(45%),其次为g相关重组(35%)。其他基因型为A1(5%)、B(2.5%)、CRF16_A2D(7.5%)和独特的重组形式(5%)。系统发育分析表明,这些菌株的来源各不相同,其中大多数可能是由移徙工人定期从中东输入的。结论:这是第一个描述孟加拉国HIV-1毒株综合特征的研究。与适当咨询和提供有关艾滋病毒传播风险的信息有关的调整干预方案需要针对返回的移徙工人。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Migrant workers play a key role in HIV-1 strain diversity in Bangladesh
Introduction: Bangladesh is a low prevalence country for human immunodeficiency virus (HIV), and genotyping data is limited which is incomplete and mainly subtype C based on gag gene. In the present paper, we characterized HIV-1 strains obtained from individuals attending three HIV testing and counseling (HTC) centers from different geographic regions in Bangladesh comprehensively based on three genes. Material and methods: A total of 40 HIV-positive blood specimens with demographic and migration history were available from individuals who attended HTC centers during 2005-2007. DNA was extracted from whole blood and sequenced using primers specific for gag, pol, and env region of HIV genome. Results: Sub-type C was the most predominant strain (45%) followed by G-related recombinants (35%). Other genotypes were A1 (5%), B (2.5%), CRF16_A2D (7.5%), and unique recombinant form (5%). Phylogenetic analysis indicates that the origins of these strains varied and most of them might have been imported from the Middle East on a regular basis by migrant workers. Conclusions: This is the first study to describe comprehensive characterization of Bangladeshi HIV-1 strains. Adapted intervention programs relating to appropriate counseling and provision of information relating to risk of transmission of HIV need to aim at returnee migrant workers.
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来源期刊
HIV & AIDS Review
HIV & AIDS Review INFECTIOUS DISEASES-
CiteScore
0.50
自引率
0.00%
发文量
30
审稿时长
12 weeks
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