In Vitro Methods Used for Simulation of Skin Functions; Application in Skin Care Products

The skin is the largest organ in mammals and serves as a protective barrier at the interface between the human body and the surrounding environment. It guards the underlying organs and protects the body against pathogens and microorganisms. Accordingly, it is directly exposed to potentially harmful microbial, thermal, mechanical and chemical influences. Simulating skin function aims for different biomaterials evaluation and for explorations of fundamental biological processes. In this mini review, we summarize in vitro methods that simulate skin hydration, aging and photoaging process, wound healing and menopause, high lightening novel efforts in the design of in vitro studies for the development of skin care products.