2010米提卡

IF 0.1
A. Hasugian, Heri Wibowo, Emiliana Tjitra
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Cytokines were presented in ratio of TNFα/IL10, IFNγ/IL10, and IL12/IL10. The association thrombocytopenia, parasitaemia and cytokines were determined by logistic multivariate analysis. A total 76 subjects were recruited, 51.3% infected with P. falciparum and 48.7% infected with P. vivax infection. The mean age of subjects was 15 (range: 5 – 55) years and 82.9% with thrombocytopenia (platelet range:18958-341123/mm ). The geometric mean of parasitemia was 3393 (43–412503) /mm , while the median of ratios TNFα/IL10, IFN γ/IL10 and IL12/IL10 were 1.05; 0.99; and 0.99, respectively. Bivariate anaylsis showed that trombocytopenia was associated with low level of TNFα/IL10 (p=0.015) and IL12/IL10 (0.020). The multivariate anaysis data also showed a relationship between thrombocytopenia and ratio of TNFα/IL10 with adjusted OR of 7,33 (95%CI: 1,5–35,8), p=0.014. Thrombocytopenia is associated with low ratio of TNFα/IL10 in patients with uncomplicated infection of P. falciparum and P.vivax. \nAbstrakTrombositopenia berhubungan dengan tingkat keparahan malaria. Parasitemia dan sistem kekebalan tubuh memiliki peran penting pada manifestasi infeksi malaria termasuk trombositopenia. Oleh karenanya penelitian ini bertujuan untuk menentukan hubungan antara trombositopenia, parasitemia, dan sitokin pada Plasmodium falciparum dan P.vivax. Disain studi adalah potong lintang, dilaksanakan di Rumah Sakit Mitra Masyarakat, Timika, Papua pada tahun 2010. Subjek penelitian adalah semua kelompok umur dengan malaria tanpa komplikasi. Pada perekrutan, karakteristik subjek akan dicatat, parasitemia dihitung dengan mikroskop, trombosit diukur dengan Hematology analyzer (Sysmex) dan sitokin diukur dengan Multiplex Flow Cytometry Assay (Luminex). Trombositopenia didefinisikan jika jumlah trombosit < 150.000 mm . Sitokin yang dipaparkan adalah rasio TNFα/IL10, IFNγ/IL10, dan IL12/IL10. Hubungan trombositopenia, parasitemia, dan sitokin ditentukan dengan analisis multivariat logistik. Sebanyak 76 subjek malaria mono-infeksi direkrut, 51,3% terinfeksi P. falciparum dan 48,7% P. vivax. Rata-rata umur subjek adalah 15 (kisaran : 5-55) tahun dan 82,9% dengan trombositopenia (kisaran : 18.958-341.123/ mm 3 3 ). Rerata geometrik parasitemia adalah 3393 (43-412503)/mm , sedangkan median masing–masing rasio TNFα/IL10, IFNγ/IL10 dan IL12/IL10 yaitu 1,05, 0,99; dan 0,99. Analsis bivariat menunjukkan bahwa trombositopenia berhubungan dengan rendahnya tingkat TNFα/IL10 (p = 0,015) dan tingginya rasio IL12/ IL10 (p=0,020). Hasil analisis multivariat menunjukkan adanya hubungan antara trombositopenia dan rasio TNFα/IL10 rendah (< 1,05) dengan OR: 7,33 (95% CI: 1,5-35,8), p = 0,014. 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引用次数: 2

摘要

【摘要】原细胞减少症与疟疾的严重程度有关。寄生虫病和免疫系统在包括血小板减少症在内的疟疾感染反应中起重要作用。因此,我们进行了一项研究,以确定恶性疟原虫和间日疟原虫的血小板减少症、寄生虫血症和细胞因子之间的关系。这是2010年在巴布亚蒂米卡Mitra Masyarakat医院进行的一项横断面和基于医院的研究。研究对象均为患有非复杂性疟疾的年龄组。入院时记录特征,显微镜下计算寄生虫率,血液学分析仪(Sysmex)测定血小板,多重流式细胞术(Luminex)测定细胞因子。血小板计数<150,000/mm为血小板减少症。细胞因子以TNFα/IL10、IFNγ/IL10、IL12/IL10比值表示。通过logistic多因素分析确定血小板减少、寄生虫血症和细胞因子的相关性。共招募76名受试者,其中51.3%感染恶性疟原虫,48.7%感染间日疟原虫。受试者的平均年龄为15岁(范围:5 - 55岁),82.9%患有血小板减少症(血小板范围:18958-341123/mm)。寄生虫病几何平均值为3393 (43 ~ 412503)/mm, TNFα/IL10、IFN γ/IL10和IL12/IL10比值中位数为1.05;0.99;分别是0.99。双因素分析显示,血小板减少症与TNFα/IL10 (p=0.015)和IL12/IL10 (p= 0.020)水平低相关。多因素分析数据也显示血小板减少与TNFα/ il - 10比值呈正相关,校正OR为7,33 (95%CI: 1,5 - 35,8), p=0.014。恶性疟原虫和间日疟原虫无并发症感染患者血小板减少与TNFα/ il - 10比值低相关。【摘要】恙虫病与疟疾的关系。寄生虫病与寄生虫病系统的关系及其与寄生虫病的关系。疟疾,寄生虫病,恶性疟原虫和间日疟原虫。Disain studi adalah potong lintang, dilaksanakan di Rumah Sakit Mitra Masyarakat, Timika,巴布亚帕达,2010年。科目:penelitian adalah semua kelompok umur dengan疟疾tanpa komplikasi。Pada perekrutan, karakteristik subjek akan dicatat, parasitemia dihitung dengan mickroskop, trobosit diukur dengan血液学分析仪(Sysmex)和sitokin diukur dengan多重流式细胞术检测(Luminex)。Trombositopenia didefinisikan jika jumlah trombosit < 150.000 mm。与TNFα/IL10、IFNγ/IL10、IL12/IL10的关系。多变量logistic分析:嗜氧杆菌减少症、寄生虫病、单胞菌血症。Sebanyak 76例直接单染疟,恶性疟51.3%,间日疟48.7%。Rata-rata umur subjek adalah 15 (kisaran: 5-55) tahun dan 82,9% dengan trobositopenia (kisaran: 18.958-341.123/ mm 33)。Rerata geometrik parasitemia adalah 3393 (43-412503)/mm, sedangkan中位聚集比TNFα/IL10, IFNγ/IL10和IL12/IL10 yaitu 1,05, 0,99;丹0,99。分析双变量menunjukkan bahwa trobositopenia berhubungan dengan rendahnya tingkat TNFα/IL10 (p= 0.015)和tingginya rasio IL12/ IL10 (p= 0.020)。多变量分析:menunjukkan adanya hubungan antara trobositopenia与TNFα/IL10的相关性(< 1,05),OR: 7,33 (95% CI: 1,5-35,8), p = 0,014。恶性疟原虫、间日疟原虫、间日疟原虫、白蛉、白蛉、白蛉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hubungan Trombositopenia, Parasitemia serta Mediator Pro dan Anti Inflamasi pada Infeksi Malaria, Timika 2010
AbstractTrombocytopenia is related with severity of malaria. Parasitaemia and immune system have important roles for the reactions that occur in malaria infections including thrombocytopenia. Therefore, we conducted a study to determine the association between thrombocytopenia, parasitaemia and cytokines in Plasmodium falciparum and P.vivax. This was a cross-sectional and hospital based study at Mitra Masyarakat Hospital,Timika, Papua, in 2010. Subjects were all age groups with uncomplicated malaria. On admission, characteristics subjects were recorded, parasitaemia was calculated by using microscope, platelets were measured by Hematology analyzer (Sysmex), and cytokines were measured by Multiplex Flow Cytometry Assay (Luminex).Thrombocytopenia was defined if platelet count <150,000/mm . Cytokines were presented in ratio of TNFα/IL10, IFNγ/IL10, and IL12/IL10. The association thrombocytopenia, parasitaemia and cytokines were determined by logistic multivariate analysis. A total 76 subjects were recruited, 51.3% infected with P. falciparum and 48.7% infected with P. vivax infection. The mean age of subjects was 15 (range: 5 – 55) years and 82.9% with thrombocytopenia (platelet range:18958-341123/mm ). The geometric mean of parasitemia was 3393 (43–412503) /mm , while the median of ratios TNFα/IL10, IFN γ/IL10 and IL12/IL10 were 1.05; 0.99; and 0.99, respectively. Bivariate anaylsis showed that trombocytopenia was associated with low level of TNFα/IL10 (p=0.015) and IL12/IL10 (0.020). The multivariate anaysis data also showed a relationship between thrombocytopenia and ratio of TNFα/IL10 with adjusted OR of 7,33 (95%CI: 1,5–35,8), p=0.014. Thrombocytopenia is associated with low ratio of TNFα/IL10 in patients with uncomplicated infection of P. falciparum and P.vivax. AbstrakTrombositopenia berhubungan dengan tingkat keparahan malaria. Parasitemia dan sistem kekebalan tubuh memiliki peran penting pada manifestasi infeksi malaria termasuk trombositopenia. Oleh karenanya penelitian ini bertujuan untuk menentukan hubungan antara trombositopenia, parasitemia, dan sitokin pada Plasmodium falciparum dan P.vivax. Disain studi adalah potong lintang, dilaksanakan di Rumah Sakit Mitra Masyarakat, Timika, Papua pada tahun 2010. Subjek penelitian adalah semua kelompok umur dengan malaria tanpa komplikasi. Pada perekrutan, karakteristik subjek akan dicatat, parasitemia dihitung dengan mikroskop, trombosit diukur dengan Hematology analyzer (Sysmex) dan sitokin diukur dengan Multiplex Flow Cytometry Assay (Luminex). Trombositopenia didefinisikan jika jumlah trombosit < 150.000 mm . Sitokin yang dipaparkan adalah rasio TNFα/IL10, IFNγ/IL10, dan IL12/IL10. Hubungan trombositopenia, parasitemia, dan sitokin ditentukan dengan analisis multivariat logistik. Sebanyak 76 subjek malaria mono-infeksi direkrut, 51,3% terinfeksi P. falciparum dan 48,7% P. vivax. Rata-rata umur subjek adalah 15 (kisaran : 5-55) tahun dan 82,9% dengan trombositopenia (kisaran : 18.958-341.123/ mm 3 3 ). Rerata geometrik parasitemia adalah 3393 (43-412503)/mm , sedangkan median masing–masing rasio TNFα/IL10, IFNγ/IL10 dan IL12/IL10 yaitu 1,05, 0,99; dan 0,99. Analsis bivariat menunjukkan bahwa trombositopenia berhubungan dengan rendahnya tingkat TNFα/IL10 (p = 0,015) dan tingginya rasio IL12/ IL10 (p=0,020). Hasil analisis multivariat menunjukkan adanya hubungan antara trombositopenia dan rasio TNFα/IL10 rendah (< 1,05) dengan OR: 7,33 (95% CI: 1,5-35,8), p = 0,014. Trombositopenia dikaitkan dengan rendahnya rasio TNFα/ IL10 pada pasien infeksi dari P. falciparum dan P. vivax tanpa komplikasi.
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来源期刊
Media Penelitian dan Pengembangan Kesehatan
Media Penelitian dan Pengembangan Kesehatan PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
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