体内评价:含有金合欢树皮提取物的乳膏对皮肤黑色素和红斑含量的影响

Atif Ali, N. Akhtar, Muhammad Shoaib Khan
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引用次数: 16

摘要

酚类化合物对酪氨酸酶和炎症活性有抑制作用,导致黑色素和红斑含量减少。这对色素沉着、皮炎和其他氧化应激疾病很重要。目的:研究金合欢树皮富酚提取物乳膏对人体皮肤黑色素和红斑含量的影响。材料和方法:对11名健康男性志愿者进行分析,并通过非侵入性生物工程技术对其进行为期三个月的活性面霜和基础治疗。结果:贴片试验后未见严重不良反应。应用方差分析(ANOVA)进行统计分析后,基础霜的效果不显著,活性霜的皮肤黑色素和红斑含量显著降低。结论:我们的研究结果表明,金合欢树皮提取物是天然产生的酚类化合物的宝贵来源。含有富含酚的金合欢树皮提取物的活性乳膏治疗人体皮肤,可显著减少体内皮肤黑色素和红斑,可用于局部治疗色素沉着和皮炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Original paper In vivo evaluation: the effects of a cream containing Acacia bark extract on skin melanin and erythema content
Introduction: Phenolic compounds have inhibitory effects on tyrosinase and inflammatory activities which lead to reduction in the melanin and erythema content. This is important for hyperpigmentation, dermatitis and other oxidative stress diseases. Aim: Investigation of the effects of a cream containing phenolic-rich extract of Acacia bark on the human skin melanin and erythema content. Material and methods: Eleven healthy male volunteers were analyzed and treated with active cream versus base for a period of three months by non-invasive bioengineering techniques. Results: No serious adverse effects were observed after patch testing. Base showed insignificant results and active cream showed a significant decrease in skin melanin and erythema content after statistically applied ANOVA. Conclusions: Our results show that the Acacia bark extract represents a valuable source of phenolic compounds produced naturally. Treatments of human skin with active cream containing phenolic-rich Acacia bark extract sig nificantly reduce skin melanin and erythema in vivo and could be used for topical treatment of hyperpigmentation and dermatitis.
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