L. Miranda, Kátia Lucia Gonçalves Cunha, I. Barbosa, T. J. Masson, Antônio Hortencio Munhoz Junior
{"title":"基于PVP/PVAL/壳聚糖的伪薄水铝石纳米颗粒水凝胶的制备及其药物应用","authors":"L. Miranda, Kátia Lucia Gonçalves Cunha, I. Barbosa, T. J. Masson, Antônio Hortencio Munhoz Junior","doi":"10.5772/INTECHOPEN.72007","DOIUrl":null,"url":null,"abstract":"Peoplewithskinlesionscausedbyburns,ulcerationsandothercomplications,independentofdegreeandextensionoftheproblem,hasinducedthesearchformethodsandmaterialstooptimizetheprocessoftissuerepairinmatteroftimeandquality.Thus,materialsmadebysyntheticpolymershavebeenusedandimprovedduetooverwhelmingdemand.Theefficacyofdressingsandbandagedependsonavarietyoffactorssuchasbiocompatibility,compositionuniformity,lowcost,longvalidity,flexibility,andsoon.Inthischapter,hydro-philicmembranesbasedonpolyvinylpyrrolidone-PVP/poly(vinylalcohol)-PVAland chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electron-beam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physi- cochemicaltests.Pseudoboehmitenanoparticles wereobtainedfrom aluminumnitrate bya sol – gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling,greaterattractionandgreaterresistancetoelongationatbreakintension,althoughsignificantlylowerfractionofgelmembranescontainsonlyagarandPVP.Itwasverifiedthatthepresenceofchitosannanoparticlesandpseudoboehmitepromotesadecreaseintheformationofcross-linksduringirradiationofhydrophilicmembranes. with higher mechanical properties, the dose irradiation must be increased to increase the density of cross-links.","PeriodicalId":13011,"journal":{"name":"Hydrogels","volume":"44 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs\",\"authors\":\"L. Miranda, Kátia Lucia Gonçalves Cunha, I. Barbosa, T. J. Masson, Antônio Hortencio Munhoz Junior\",\"doi\":\"10.5772/INTECHOPEN.72007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Peoplewithskinlesionscausedbyburns,ulcerationsandothercomplications,independentofdegreeandextensionoftheproblem,hasinducedthesearchformethodsandmaterialstooptimizetheprocessoftissuerepairinmatteroftimeandquality.Thus,materialsmadebysyntheticpolymershavebeenusedandimprovedduetooverwhelmingdemand.Theefficacyofdressingsandbandagedependsonavarietyoffactorssuchasbiocompatibility,compositionuniformity,lowcost,longvalidity,flexibility,andsoon.Inthischapter,hydro-philicmembranesbasedonpolyvinylpyrrolidone-PVP/poly(vinylalcohol)-PVAland chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electron-beam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physi- cochemicaltests.Pseudoboehmitenanoparticles wereobtainedfrom aluminumnitrate bya sol – gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling,greaterattractionandgreaterresistancetoelongationatbreakintension,althoughsignificantlylowerfractionofgelmembranescontainsonlyagarandPVP.Itwasverifiedthatthepresenceofchitosannanoparticlesandpseudoboehmitepromotesadecreaseintheformationofcross-linksduringirradiationofhydrophilicmembranes. with higher mechanical properties, the dose irradiation must be increased to increase the density of cross-links.\",\"PeriodicalId\":13011,\"journal\":{\"name\":\"Hydrogels\",\"volume\":\"44 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hydrogels\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5772/INTECHOPEN.72007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hydrogels","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5772/INTECHOPEN.72007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs
Peoplewithskinlesionscausedbyburns,ulcerationsandothercomplications,independentofdegreeandextensionoftheproblem,hasinducedthesearchformethodsandmaterialstooptimizetheprocessoftissuerepairinmatteroftimeandquality.Thus,materialsmadebysyntheticpolymershavebeenusedandimprovedduetooverwhelmingdemand.Theefficacyofdressingsandbandagedependsonavarietyoffactorssuchasbiocompatibility,compositionuniformity,lowcost,longvalidity,flexibility,andsoon.Inthischapter,hydro-philicmembranesbasedonpolyvinylpyrrolidone-PVP/poly(vinylalcohol)-PVAland chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electron-beam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physi- cochemicaltests.Pseudoboehmitenanoparticles wereobtainedfrom aluminumnitrate bya sol – gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling,greaterattractionandgreaterresistancetoelongationatbreakintension,althoughsignificantlylowerfractionofgelmembranescontainsonlyagarandPVP.Itwasverifiedthatthepresenceofchitosannanoparticlesandpseudoboehmitepromotesadecreaseintheformationofcross-linksduringirradiationofhydrophilicmembranes. with higher mechanical properties, the dose irradiation must be increased to increase the density of cross-links.
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