A REVIEW ON PHYTOCONSTITUENTS AND THERAPEUTIC USES OF MUQIL (COMMIPHORA MUKUL)

Muqilis one of the best drugs in traditional system of medicine since ancient. It belongs to Burseraceae family, has 540 species and is found in dry area of India known as Indian bdellium. It is bushy plant 1.2-1.8 m can provide yellowish gum resin also called as gugulipid. Most commonly gum of this plant used for therapeutic and medicinal purpose. According to Unani system of medicine (USM) it has two types: 1. Muqil-e-Saqalibi, 2. Muqil-e-Arabi. The plant Commiphora mukul is also known as Balsamodendron mukul Stock. Muqil has active constituents producing number of biological activities such as Antiinflammatory effect (guggulsterones Z and E), Osteoprotective effect (guggulsterone), Anti- inflammatory, analgesic antiarthritic activities (Guggulsterone), Anti-diabetic effect (gum resin 900 mg daily), Antimicrobial, antibacterial, antiviral and antifungal activities (Eugenol, ellagic acid alpha-pinene, masumbinoic acid and masumbinone), Anti-hemorrhoid activity (Muqil resin), Anti-neoplastic activity (GS, gugulipid and Z-guggusterone), Cardioprotective effect (gugulipid and guggusterone), Nephroprotective effect, Nodulocystic Acne (Guggulipid), Neuroprotective effects (guggulipid), Immunomodulatory effect, Stimulate Thyroid gland activity (Commiphora mukul gum) Anti-asthmatic (300 mg of gum resin thrice daily), Inflammatory Bowel Disease (gum resin at a dose of 900 mg daily). It is also useful for systemic disease such as Osteoarthritis, Rheumatoid arthritis, Gout, Cadio-protective effect and thyro-protective effect, nervous diseases and urinarydiseases. Skin disorders are leprosy, pyorrhea, muscle spasm, demulcent, and depurative.