橄榄油厂废水中多酚类物质的抗炎活性

Z. Gueboudji
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引用次数: 2

摘要

橄榄油厂废水(OMW)是橄榄油工业的副产品。它污染严重,造成严重的环境问题,但富含多酚,具有抗氧化和抗炎作用。本研究旨在体外评价从位于阿尔及利亚东部Khenchela的现代橄榄磨坊中提取的两个品种Chemlal和Zlitni的OMW酚类提取物的抗炎潜力。浸渍法提取多酚。分别用福林-环钙法和三氯化铝法测定了总多酚的用量和总黄酮的含量。两项试验比较了双氯芬酸钠的抗炎活性、抑制蛋白变性(IPD)和膜稳定电位(MSP)。结果表明,与Zlitni和标准品IC50 (IC50=98.41±1.22µg/mL)相比,Chemlal OMW酚类提取物具有最高的抗炎活性(IPD: IC50= 91.27±2.73µg/mL, MSP: IC50=98.41±1.22µg/mL)。体外实验表明,黄芪酚类提取物是天然抗炎剂的重要来源,可用于制药工业,另一方面可减少其对环境的危害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-Inflammatory Activity Of Polyphenols From Olive Oil Mill Wastewaters
Olive oil mill wastewater (OMW) is a by-product of the olive oil industry. It is very polluting and causes serious environmental problems, but is very loaded with polyphenols, which have antioxidant and anti-inflammatory power. This study aimed to evaluate in vitro the anti-inflammatory potential of the phenolic extract of OMW from two varieties, Chemlal and Zlitni, extracted from a modern olive mill located in Khenchela, eastern Algeria. The maceration method did the extraction of the polyphenols. The dosage of total polyphenols and flavonoids content was determined by Folin-Ciocalteu and aluminum trichloride methods successively. Two tests made the anti-inflammatory activity, inhibition of protein denaturation (IPD) and membrane-stabilizing potential (MSP), comparing with sodium diclofenac. The results obtained showed that the phenolic extract of OMW of Chemlal was found to exhibit the highest inhibitory effect anti-inflammatory activity (IPD: IC50 = 91.27 ± 2.73 µg/mL, and MSP: IC50=98.41 ± 1.22 µg/mL) more than the phenolic extract of Zlitni and the standard used (sodium iclofenac). The in vitro assays carried out show that the phenolic extract of OMW has an important source of natural anti-inflammatory agents, which can be used in the pharmaceutical industry and on the other hand reducing its dangerous impact on the environment.
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