血浆置换成功治疗皮质类固醇难治性嗜酸性肉芽肿病伴胃肠道表现的多血管炎

IF 0.7 Q4 IMMUNOLOGY

Case Reports in Immunology Pub Date : 2016-02-17 DOI:10.1155/2016/8341751

Kohei Tsujimoto, M. Yagita, M. Taniguchi, M. Fujita

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引用次数: 3

摘要

我们描述了一例33岁的女性患有皮质类固醇难治性嗜酸性肉芽肿病合并多血管炎(EGPA)，她表现为腹痛并对血浆交换有显著反应。嗜酸性粒细胞增多、哮喘史、神经病变、肺浸润、鼻窦异常均证实了EGPA的诊断。治疗开始时，1 g/天甲基强的松龙脉冲治疗3天，随后60 mg/天静脉注射强的松龙，不缓解腹痛。然后进行三次血浆置换。第一次血浆置换后腹痛消失。血浆置换EGPA的适应症仍有争议;然而，在胃肠道受累的情况下，它可能是一种有效的选择。

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Successful Use of Plasma Exchange in the Treatment of Corticosteroid-Refractory Eosinophilic Granulomatosis with Polyangiitis Associated with Gastrointestinal Manifestations

We describe the case of a 33-year-old woman having corticosteroid-refractory eosinophilic granulomatosis with polyangiitis (EGPA) who presented with abdominal pain and responded dramatically to plasma exchange. Eosinophilia, asthma history, neuropathy, pulmonary infiltrates, and paranasal sinus abnormalities confirmed the diagnosis of EGPA. Treatment was initiated with 1 g/day of methylprednisolone pulse therapy for 3 days followed by 60 mg/day of intravenous prednisolone without relieving abdominal pain. Then, plasma exchange was performed thrice. Abdominal pain disappeared after the first plasma exchange. Indication of plasma exchange for EGPA remains controversial; however, it may represent a valid option in cases with gastrointestinal involvement.

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来源期刊

Case Reports in Immunology IMMUNOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Case Reports in Immunology is a peer-reviewed, Open Access journal that publishes case reports and case series related to allergies, immunodeficiencies, autoimmune diseases, immune disorders, cancer immunology and transplantation immunology.