Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells

Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesia in January 2019. C. mangga rhizomes were macerated in acetone then followed by increasing polarity partitions with n-hexane, EtOAc, and methanol, subsequently. One isolated fraction was obtained from various chromatography techniques of n-Hexane fraction. The isolated fraction then was subjected by LCMS/MS. According to LC-MS/MS data, the isolated fraction was a mixture consisted of terpenoids derivatives, i.e. zedoarondiol (1), curcumenol (2), curcumenone (3), and 13-hydroxygermacrone (4). Based on literature studies, terpenoids from Indonesian Curcuma Genus could be developed as an anticancer agent to inhibit MCF-7 breast cells’ growth.