肉碱的质量评价与合理使用

Yuka Miyachi, Chika Nakayama, Taeyuki Oshima
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引用次数: 0

摘要

近年来,消费者的健康意识越来越强。补品越来越受欢迎,因为它们很容易买到。在日本,“功能声明食品”制度始于2015年;预计补充剂市场将继续扩大。然而,一些补充剂的使用并没有足够的科学证据支持;一些产品甚至造成了健康问题。此外,消费者可能无法根据互联网上的信息做出正确的决定。与药物不同,补充剂的使用说明并不精确。因此,今后提高补充剂信息的质量将变得更加必要。本研究旨在通过对含肉碱补充剂的崩解和溶出行为进行调查,并对其质量进行评价,以提高补充剂信息的质量。这里测试的产品是含有商业肉碱的补充剂。崩解试验和溶出试验按日本药典进行。采用高效液相色谱法定量测定肉碱含量。崩解试验表明,产品崩解时间不同,从35分钟到100分钟不等;有些产品需要5个多小时才能分解。因此,有些产物的溶出率上升缓慢。这些结果表明,本研究中使用的含有肉碱的补充剂可能会影响吸收过程。因此,在口服给药的情况下,根据产品的不同,可能无法达到预期的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quality Evaluation of Carnitine for Proper Use of Supplement
In recent years, consumers are becoming more health-conscious. Supplements are becoming popular as they can be purchased easily. In Japan, the “Food with Function Claims” system began in 2015; the market for supplements is expected to continue to expand. However, the use of some supplements has not been supported with sufficient scientific evidence; some products have even caused health problems. In addition, consumers may not be able to make correct decisions based on the information from the Internet. Unlike medicine, the instruction on the usage of supplements is not precise. Therefore, improving the quality of the information on the supplements will become more necessary in the future. This study aims to improve the quality of the information on supplements by surveying the disintegration and dissolution behavior of the carnitine-containing supplements and evaluated their quality. The products tested here were supplements containing commercial carnitine. Disintegration test and dissolution test were conducted according to the Japanese Pharmacopoeia. Carnitine was quantified by high-performance liquid chromatography. The disintegration tests revealed that the products had different disintegration times, varying from 35 to 100 minutes; some products took more than 5 hours to disintegrate. Thus, some products had a slow rise in their dissolution rate. These results suggest that the carnitine-containing supplements used in this study may affect the absorption process. Therefore, in the case of oral administration, the expected effect might not be achieved depending on the product.
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