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引用次数: 0
摘要
磷酸肌苷3-激酶活性调节许多细胞类型的许多细胞过程。其催化亚基p110有三种同工异构体，但其特异性尚不清楚。Okkenhaug等人培养了一只表达p110失活形式的小鼠，观察到B细胞和T细胞免疫功能受损。该研究揭示了该异构体在淋巴细胞抗原受体信号传导以及药物开发靶标中的高度选择性，非冗余作用。K. Okkenhaug, A. Bilancio, G. Farjot, H. Priddle, S. Sancho, E. Peskett, W. Pearce, S. E. Meek, A. Salpekar, M. D. Waterfield, A. J. H. Smith, B. Vanhaesebroeck, p110δ PI 3-激酶突变小鼠的B和T细胞抗原受体信号通路受损，科学，297,1031-1034(2002)。【摘要】【全文】
Phosphoinositide 3-kinase activity regulates many cell processes across many cell types. There are three isoforms of its catalytic subunit p110, but their specificity has not been clear. Okkenhaug et al. generated a mouse that expresses an inactive form of p110 and observed compromised B and T cell immune function. The study reveals a highly selective, nonredundant role for this isoform in lymphocyte antigen receptor signaling, as well as a drug-development target. K. Okkenhaug, A. Bilancio, G. Farjot, H. Priddle, S. Sancho, E. Peskett, W. Pearce, S. E. Meek, A. Salpekar, M. D. Waterfield, A. J. H. Smith, B. Vanhaesebroeck, Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice, Science 297, 1031-1034 (2002). [Abstract] [Full Text]
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