热休克转录因子1能否成为热疗的潜在靶点

Y. Tabuchi
{"title":"热休克转录因子1能否成为热疗的潜在靶点","authors":"Y. Tabuchi","doi":"10.3191/THERMALMED.28.63","DOIUrl":null,"url":null,"abstract":"Hyperthermia(HT)has been considered a promising approach in cancer therapy. However, the acquisition of thermoresistance in tumor due to several responses of tumor,such as an increase in heat shock proteins (HSPs),makes HT less effective. The induction of HSPs is mainly mediated by the activation of heat shock transcription factor 1 (HSF1). It has been shown that HSF1 is abundantly expressed in human tumor cells of various origins. Moreover, it takes part in the initiation and maintenance of tumor. Silencing of HSF1 could suppress tumor formation and enhance the effectiveness of HT. In this review,the physiological and pathological roles of HSF1 in cancer cells are summarized, and its potential as a therapeutic target for hyperthermic therapy is discussed.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2012-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Can be Heat Shock Transcription Factor 1 a Potential Target for Hyperthermic Therapy\",\"authors\":\"Y. Tabuchi\",\"doi\":\"10.3191/THERMALMED.28.63\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hyperthermia(HT)has been considered a promising approach in cancer therapy. However, the acquisition of thermoresistance in tumor due to several responses of tumor,such as an increase in heat shock proteins (HSPs),makes HT less effective. The induction of HSPs is mainly mediated by the activation of heat shock transcription factor 1 (HSF1). It has been shown that HSF1 is abundantly expressed in human tumor cells of various origins. Moreover, it takes part in the initiation and maintenance of tumor. Silencing of HSF1 could suppress tumor formation and enhance the effectiveness of HT. In this review,the physiological and pathological roles of HSF1 in cancer cells are summarized, and its potential as a therapeutic target for hyperthermic therapy is discussed.\",\"PeriodicalId\":23299,\"journal\":{\"name\":\"Thermal Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Thermal Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3191/THERMALMED.28.63\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thermal Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3191/THERMALMED.28.63","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

热疗(HT)被认为是一种很有前途的癌症治疗方法。然而,由于肿瘤的几种反应,如热休克蛋白(HSPs)的增加,在肿瘤中获得了耐热性,使得高温疗法的效果降低。热休克蛋白的诱导主要通过热休克转录因子1 (HSF1)的激活介导。已有研究表明HSF1在各种来源的人类肿瘤细胞中大量表达。此外,它还参与肿瘤的发生和维持。沉默HSF1可抑制肿瘤形成,增强HT的有效性。本文综述了HSF1在肿瘤细胞中的生理和病理作用,并讨论了其作为热疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can be Heat Shock Transcription Factor 1 a Potential Target for Hyperthermic Therapy
Hyperthermia(HT)has been considered a promising approach in cancer therapy. However, the acquisition of thermoresistance in tumor due to several responses of tumor,such as an increase in heat shock proteins (HSPs),makes HT less effective. The induction of HSPs is mainly mediated by the activation of heat shock transcription factor 1 (HSF1). It has been shown that HSF1 is abundantly expressed in human tumor cells of various origins. Moreover, it takes part in the initiation and maintenance of tumor. Silencing of HSF1 could suppress tumor formation and enhance the effectiveness of HT. In this review,the physiological and pathological roles of HSF1 in cancer cells are summarized, and its potential as a therapeutic target for hyperthermic therapy is discussed.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信