寡核苷酸药物的药物化学--过去的里程碑和未来的愿景。

Change Pub Date : 2022-05-25 DOI:10.2533/chimia.2022.466

Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent

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摘要

寡核苷酸治疗领域近年来蓬勃发展，目前已有13种获批药物，并有望在未来几年加速增长。这一领域的大部分进展是由于寡核苷酸药物化学的进步，以及对分子靶点和疾病领域的明智选择。从这个角度来看，我们描述了这类新药的增长，突出了寡核苷酸药物化学中选定的里程碑。

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Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future.

The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years. Much of the progress in this field is due to advances in the medicinal chemistry of oligonucleotides,combined with a judicious choice of molecular targets and disease areas. In this perspective, we describe the growth of this new class of drugs highlighting selected milestones in oligonucleotide medicinal chemistry.

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