高血压患者血压控制的药理作用不容忽视。

M. Ciulla, C. Benfenati, E. Gallazzi, P. Vivona, R. Meazza, F. Lombardi
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引用次数: 1

摘要

我们对预防靶器官损伤和最终心血管发病率和死亡率的长期治疗策略的愿景需要持续监测和更新,至少有三个问题:1-达到预期获益所需的目标压力需要持续监测,药物剂量调整,通常需要使用联合治疗;2-某些药物的长期使用,即使是联合使用,也可能与副作用的发生有关;人口预期寿命的增加不可避免地与药物使用的增加以及不可避免地发生药物不良反应有关,其中一些不良反应会干扰血压的控制。这些问题仍未得到充分研究,在实施适当的预防战略方面造成相当大的问题。在这篇综述中,我们将评估降压治疗的目标,以及它的弱点,如频繁的副作用,导致治疗依从性差。此外,我们将回顾抗高血压药物与其他常见疾病药物之间的相互作用,以及它们在未达到预期血压降低中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacological Interactions on Blood Pressure Control in Arterial Hypertension, An Issue not to be Overlooked.
Our vision of long-term treatment strategies for the prevention of target organ damage and eventually cardiovascular morbidity and mortality in essential arterial hypertension needs to be continually monitored and updated for at least three issues: 1--the achievement of target pressure required to obtain the expected benefit needs continuous monitoring, a dose adjustment of the drug and, often, the use of combination therapies; 2--the chronic use of certain drugs, even in combination, is associated with the possible onset of side effects; 3--increasing of population life expectancy is inevitably associated with in an increase in drugs use with the unavoidable occurrence of adverse drug reactions, some of which can interfere with blood pressure control. These issues, still poorly studied, pose considerable problems in applying proper strategies for prevention. In this review, we will evaluate the goals of antihypertensive therapy, and its weak spots, such as the frequent side effects, that lead to poor therapy compliance. Moreover, we will review the interactions between antihypertensive and drugs used for other common disease, and their importance in not achieving the expected blood pressure reduction.
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