METCAM/MUC18:一种新的肿瘤抑制因子

Q2 Biochemistry, Genetics and Molecular Biology

Genes and Cancer Pub Date : 2019-05-18 DOI:10.5772/intechopen.86271

Guang-Jer Wu

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引用次数: 1

摘要

METCAM/MUC18是igg样基因超家族中的一种细胞粘附分子(CAM)，是细胞膜的组成部分。它能够完成cam的一般功能，如在肿瘤微环境中进行细胞间相互作用和细胞与细胞外基质的相互作用，与各种信号通路相互作用，调节细胞的社会行为。METCAM/MUC18在某些癌症中发挥抑瘤功能，如结直肠癌、鼻咽癌I型、一种小鼠黑色素瘤亚群K1735-9、卵巢癌、胰腺癌、前列腺癌PC-3细胞系，可能还有血管瘤。提出了METCAM/ muc18介导的肿瘤抑制的可能机制。利用METCAM/MUC18的抑瘤功能，重组METCAM/MUC18蛋白及其衍生产物可作为治疗这些癌症的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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METCAM/MUC18: A Novel Tumor Suppressor for Some Cancers

METCAM/MUC18, a component of cellular membrane, is a cell adhesion molecule (CAM) in the Ig-like gene super-family. It is capable of carrying out general functions of CAMs, such as performing intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, interacting with various signaling pathways, and regulating social behaviors of cells. METCAM/MUC18 plays the tumor suppressor function in some cancers, such as colorectal cancer, nasopharyngeal carcinoma type I, one mouse melanoma subline K1735-9, ovarian cancer, pancreatic cancer, prostate cancer PC-3 cell line, and perhaps hemangioma. Possible mechanism in the METCAM/MUC18-mediated tumor suppression is pro-posed. By taking advantage of the tumor suppressor function of METCAM/MUC18, recombinant METCAM/MUC18 proteins and other derived products may be used as therapeutic agents to treat these cancers.

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来源期刊

Genes and Cancer Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.90

自引率

0.00%

发文量