新型半夹心镧(III)、铒(III)、镱(III)配合物有机金属二茂铁席夫碱配体是否具有抗菌和抗癌的生物活性?

IF 3.8 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Comments on Inorganic Chemistry Pub Date : 2022-06-29 DOI:10.1080/02603594.2022.2083608

Reem G. Deghadi, G. Mohamed

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引用次数: 8

摘要

摘要以二茂铁基席夫碱配体(2-(1-(8-氨基萘-1-基)亚氨基)乙基)环戊二烯-2,4-二烯-1-基)铁(L1)和(2-(1-羧乙基)亚氨基)乙基)环戊二烯-2,4-二烯-1-基)铁(HL2)为原料合成了一系列新的La(III)、Er(III)和Yb(III)配合物。配合物的设计，合成和表征使用各种光谱技术。摩尔电导数据表明，除La(III)-HL2配合物为非电解质外，其他配合物均为电解质。红外光谱表明，席夫碱与过渡金属离子呈双齿配位，N,N给体位与L1配位，N,O给体位与HL2配位。所有配合物均为八面体，与配体的摩尔比为1:1。研究了配合物的热行为。对4种革兰氏阳性菌(金黄色葡萄球菌、蜡样芽孢杆菌、枯草芽孢杆菌、粪链球菌)和4种革兰氏阴性菌(大肠埃希菌、铜绿假单胞菌、淋病奈瑟菌、鼠伤寒沙门菌)的体外抑菌活性进行了评价，结果表明化合物具有生物活性。此外，还评估了它们对乳腺癌细胞系MCF-7的抗癌活性。最后，对所有制备的含两种不同COVID-19受体(7BZ5和7C8J)的化合物进行分子对接研究，并对乳腺癌3HB5受体进行了分子对接研究。分子对接表明标题化合物与三种蛋白质受体之间具有良好的相互作用。这篇论文展示了一种新颖的传统，即《无机化学评论》开始发表原创的研究内容，尽管如此，它仍然保留了《无机化学评论》作为当代无机化学文学批判性讨论的利基的身份;有关以前的表现，请参阅Comments Inorg。化学，2020,40,277-303，参考文献摘要。图形抽象

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Can New Series of Half-sandwich Lanthanum(III), Erbium(III), and Ytterbium(III) Complexes of Organometallic Ferrocenyl Schiff Base Ligands Display Biological Activities as Antibacterial and Anticancer Drugs?

ABSTRACT A new series of La(III), Er(III), and Yb(III) complexes were synthesized from ferrocenyl Schiff base ligands (2-(1-((8-aminonaphthalen-1-yl)imino)ethyl)cyclopenta-2,4-dien-1-yl) (cyclopenta-2,4-dien-1-yl)iron (L1) and (2-(1-((1-carboxyethyl)imino)ethyl) cyclopenta-2,4-dien-1-yl)(cyclopenta-2,4-dien-1-yl)iron (HL2). Complexes were designed, synthesized, and characterized using various spectroscopic techniques. Molar conductance data exposed that the complexes were electrolytes except La(III)-HL2 complex, which was non-electrolyte. IR spectra denoted that Schiff bases were coordinated with transition metal ions in a bidentate manner, N,N donor sites with L1 and N,O donor sites with HL2. All complexes were octahedral and prepared in a 1:1 molar ratio with the ligands. Thermal behavior of the complexes was studied. The in vitro antibacterial activities of these compounds were evaluated against eight bacterial species such as four Gram positive bacteria (Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Streptococcus faecalis), and four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Salmonella typhimurium) and results displayed that title compounds are biologically active. Also, they were assessed for their anticancer activities against cell line MCF-7 for breast cancer. Finally, molecular docking studies were tested for all prepared compounds with two different COVID-19 receptors (7BZ5 and 7C8J), also, against 3HB5 receptor of breast cancer. Molecular docking has shown favorable interaction between the title compounds and three protein receptors. This paper affords a manifestation of a novel tradition by which Comments on Inorganic Chemistry starts publishing original research content that, nonetheless, preserves the Journal’s identity as a niche for a critical discussion of contemporary literature in inorganic chemistry; for previous manifestations, see Comments Inorg. Chem. 2020, 40, 277–303, and references cited in the abstract thereof. GRAPHICAL ABSTRACT

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来源期刊

Comments on Inorganic Chemistry 化学-无机化学与核化学

CiteScore

9.00

自引率

1.90%

发文量

审稿时长

>12 weeks

期刊介绍： Comments on Inorganic Chemistry is intended as a vehicle for authoritatively written critical discussions of inorganic chemistry research. We publish focused articles of any length that critique or comment upon new concepts, or which introduce new interpretations or developments of long-standing concepts. “Comments” may contain critical discussions of previously published work, or original research that critiques existing concepts or introduces novel concepts. Through the medium of “comments,” the Editors encourage authors in any area of inorganic chemistry - synthesis, structure, spectroscopy, kinetics and mechanisms, theory - to write about their interests in a manner that is both personal and pedagogical. Comments is an excellent platform for younger inorganic chemists whose research is not yet widely known to describe their work, and add to the spectrum of Comments’ author profiles, which includes many well-established inorganic chemists.