成人神经母细胞瘤:哪种治疗有效?

F. Karaca, ÇiÄdem Usul AfÅar, Meral GünaldÄ, Berksoy Åahin
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引用次数: 0

摘要

检查一名28岁男性腰痛患者,发现肿块延伸至L1-L2水平的椎管,并表现出与腰肌难以区分的左侧椎旁延伸。神经母细胞瘤是在活检后确诊的。在同一年和接下来的几年里,即使在接受手术、放疗、化疗和骨髓移植后,病情仍在恶化。病程对不同的大剂量化疗和放疗具有耐药性。该患者在确诊后4年死亡。神经母细胞瘤是一种常见于儿童的肿瘤,在成人中被视为一种晚期或转移性疾病。目前成人神经母细胞瘤没有标准的治疗方法。适用于儿童的治疗方案不适用于成人。一般来说,神经母细胞瘤的特点是局部疾病,但在成人中,它更具侵袭性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroblastoma in the Adult: Which Therapy is Effective?
The examination of a twenty-eight-year-old male patient with lower back pain revealed a mass that extended through the spinal canal at the L1-L2 level and exhibited left paravertebral extension which was indistinguishable from the psoas muscle. Neuroblastoma was diagnosed after performing a biopsy. The disease progressed in that same year and in the following years, even after performing surgery, radiotherapy, chemotherapy, and bone marrow transplantation. The course of the disease was resistant to different high-dose chemotherapies and radiotherapy. The patient died four years after diagnosis. Neuroblastoma, a tumor which more frequently appears in children, is seen as an advanced or metastatic disease in adults. Currently there is no standard treatment for neuroblastoma in adults. The treatment protocols applied in children are insufficient for adults. Generally neuroblastoma is characterized as a localized disease, but in adults it is more aggressive.
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