左炔诺孕酮宫内系统的避孕应用:病例系列

Zeynep Ayaz, A. Uzuner
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摘要

目的:左炔诺孕酮宫内系统(LNG-RIS)是一种高效、安全、可逆的避孕方法。它抑制子宫内膜细胞增殖,增厚宫颈粘液,通过在子宫内膜和输卵管粘膜中产生高左炔诺孕酮浓度来破坏输卵管运动。在我国,LNG-RIS多用于妇产科诊所,用于治疗子宫腺肌症、子宫内膜异位症、增生等病理及其症状,如月经过多、痛经、盆腔疼痛等,并因用药报告而在医院开处方。它具有高水平的保护(99.9%),其避孕效果被认为持续五年,并且在去除后迅速恢复生育能力。本研究旨在回顾性评估LNG-RIS植入后的延续率、不良反应的存在以及患者满意度。方法:这是一项回顾性描述性研究,对2013-2019年在马尔马拉大学潘迪克培训和研究医院计划生育部门植入LNG-IUS避孕目的的妇女进行研究;回顾性分析38例患者的资料。结果:患者平均年龄36±5岁。在使用该方法期间未发现怀孕。用户的五年使用率为21%。共有9名患者停止了该方法;一个是因为被诊断出患有神经胶质瘤,两个是因为出血过多,另一个是因为子宫肌瘤而进行子宫切除术,两个是因为线看不见,另外两个是因为他们被告知他们的LNG-IUS滑落了一个是因为她的怀孕计划。满意度为52.6%。月经持续时间和出血量都有所减少,但这种减少在统计学上并不显著。结论:LNG-RIS是一种有效、可靠、副作用小的避孕方法。它在初级保健方面仍然有限,推广使用将更为合适。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contraceptive Use of Levonorgestrel Intrauterine System: Case Series
Aim: Levonorgestrel intrauterine system (LNG-RIS) is a highly effective, safe and reversible contraceptive method. It suppresses endometrial cell proliferation, thickens cervical mucus, disrupts tubal motility by creating a high levonorgestrel concentration in the endometrium and tubal mucosa. In our country, LNG-RIS is mostly used in Gynecology and Obstetrics clinics in the treatment of pathologies such as adenomyosis, endometriosis, hyperplasia and their symptoms such as menorrhagia, dysmenorrhea, pelvic pain, and is prescribed at the hospitals due to a medication report. It has a high level of protection (99.9%), and its contraceptive effect is considered to last five years, and fertility returns rapidly after removal. In this study it was aimed to evaluate retrospectively the continuation rate, the presence of unwanted effects and the patient satisfaction after insertion of LNG-RIS. Method: This is a retrospective, descriptive study of women who had been inserted LNG-IUS with contraceptive purpose in the family planning unit of the Marmara University Pendik Training and Research Hospital, between 2013-2019; the data of a total 38 patients were retrospectively analyzed. Results: The average age of the participants was 36±5 years. No pregnancy is detected during the use of the method. Five-year usage rate was 21% among users. A total of nine patients discontinued the method; one because being diagnosed with a glial tumor, two because of excessive bleeding, one other patient because having hysterectomy due to myoma uteri, two patients because the threads were not visible, two others because they have been told that their LNG-IUS had slipped down and one patient because of her pregnancy plan. The satisfaction rate was 52.6%. There was a decrease in both the duration and the amount of bleeding of menstruation but this decrease was not statistically significant. Conclusion: LNG-RIS is an effective, reliable contraception method with low side effect. It is still limited in primary care and it will be more appropriate to spread its use.
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