{"title":"亚临床甲状腺功能减退症的内皮相关心血管危险因素","authors":"V. Samitin, T. Rodionova","doi":"10.14341/KET20095126-29","DOIUrl":null,"url":null,"abstract":"The aim of the study was to evaluate the endothelial function in patients with subclinical hypothyroidism. 39 patients and a control group of 14 matched persons group were included in cross-sectional research. In subclinical hypothyroid patients endothelium-dependent vasodilatation significantly decreased, while endothelin-1 and PAI-1 levels increased. Levels of total cholesterol and low-density lipoproteins were significantly higher in patients with subclinical hypothyroidism than in control group, and their positive correlation with TSH was revealed. These findings allow us to make a conclusion on presence of endothelial dysfunction and atherogenic dislipoproteinemia in patients with subclinical hypothyroidism.","PeriodicalId":10284,"journal":{"name":"Clinical and experimental thyroidology","volume":"43 1","pages":"26-29"},"PeriodicalIF":0.0000,"publicationDate":"2009-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Endothelium-related Cardiovascular Risk Factors in Subclinical Hypothyroidism\",\"authors\":\"V. Samitin, T. Rodionova\",\"doi\":\"10.14341/KET20095126-29\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of the study was to evaluate the endothelial function in patients with subclinical hypothyroidism. 39 patients and a control group of 14 matched persons group were included in cross-sectional research. In subclinical hypothyroid patients endothelium-dependent vasodilatation significantly decreased, while endothelin-1 and PAI-1 levels increased. Levels of total cholesterol and low-density lipoproteins were significantly higher in patients with subclinical hypothyroidism than in control group, and their positive correlation with TSH was revealed. These findings allow us to make a conclusion on presence of endothelial dysfunction and atherogenic dislipoproteinemia in patients with subclinical hypothyroidism.\",\"PeriodicalId\":10284,\"journal\":{\"name\":\"Clinical and experimental thyroidology\",\"volume\":\"43 1\",\"pages\":\"26-29\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and experimental thyroidology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14341/KET20095126-29\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and experimental thyroidology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14341/KET20095126-29","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Endothelium-related Cardiovascular Risk Factors in Subclinical Hypothyroidism
The aim of the study was to evaluate the endothelial function in patients with subclinical hypothyroidism. 39 patients and a control group of 14 matched persons group were included in cross-sectional research. In subclinical hypothyroid patients endothelium-dependent vasodilatation significantly decreased, while endothelin-1 and PAI-1 levels increased. Levels of total cholesterol and low-density lipoproteins were significantly higher in patients with subclinical hypothyroidism than in control group, and their positive correlation with TSH was revealed. These findings allow us to make a conclusion on presence of endothelial dysfunction and atherogenic dislipoproteinemia in patients with subclinical hypothyroidism.
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