双凝胶:一种新型经皮给药材料

S. Rajeswari, Rajeswari Pullabhatla, C. Satyavathi
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引用次数: 0

摘要

双凝胶半固体配方是有机凝胶和水凝胶的组合,具有较好的应用性能,如制药和化妆品。本文就双凝胶作为经皮给药载体的应用作一综述。它包含极性和非极性两种不同的相,因此它具有一些显著的特征,如能够传递亲疏水药物,同时具有提高药物的渗透性,更好的扩散能力和水洗能力。因此,凝胶既有有机凝胶也有水凝胶,它们可以增强角质层的水化作用,也有能力控制药物从剂量中释放出来的速度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BI-GELS: A NOVEL MATERIAL FOR TRANSDERMAL DRUG DELIVERY
Bi-gels semi solid formulation is combination of organogel and hydrogel with better application property such as pharmaceutical and cosmetics. The main objective of this review is specially focuses on application of bi-gels as drug delivery vehicles by transdermal route. It contains two different phases which are polar and nonpolar due to which, it possess some significant features such as ability to deliver the hydrophilic and hydrophobic drugs which also have improved permeability of drugs, better spreading ability, and water wash ability. Hence, bigels have both organogels and hydrogels they can enhanced hydration of stratum corneum and also had an ability to manipulate the drug release rate from the dosage from.
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