患有COVID-19和患病后12个月的生殖后妇女的甲状腺状态和tnf - α

Q4 Immunology and Microbiology

Acta Biomedica Scientifica Pub Date : 2023-05-03 DOI:10.29413/abs.2023-8.2.4

N. Semenova, S. Kolesnikov, E. V. Vyrupaeva, L. Sholokhov, L. V. Rychkova, А. G. Petrova, M. R. Akhmedzyanova, M. Darenskaya, L. Kolesnikova

{"title":"患有COVID-19和患病后12个月的生殖后妇女的甲状腺状态和tnf - α","authors":"N. Semenova, S. Kolesnikov, E. V. Vyrupaeva, L. Sholokhov, L. V. Rychkova, А. G. Petrova, M. R. Akhmedzyanova, M. Darenskaya, L. Kolesnikova","doi":"10.29413/abs.2023-8.2.4","DOIUrl":null,"url":null,"abstract":"The aim. To assess the thyroid status and its relationship with tumor necrosis factor alpha (TNF-alpha) in post-reproductive women in the acute phase of the COVID-19 of moderate course and 12 months after the disease.Materials and methods. 85 women aged 45 to 69 years were divided into groups: women without COVID-19, not vaccinated, with no antibodies to COVID-19 (IgG) – control group (n = 15); women in the acute phase of COVID-19 of a moderate course, accompanied by pneumonia – main group (n = 57); patients from the main group who agreed to be examined 12 months after having COVID-19 (n = 14); women with IgG in blood who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19 (n = 13). Using hormone replacement therapy and the presence of thyroid disease in history were the exclusion criteria from the study.Results. 75.4 % of patients with COVID-19 had euthyroidism, 12.3 % had subclinical hyperthyroidism. An increase of free thyroxine (free T4) level in women with COVID-19 as compared to the control group (p = 0.004) and the group with asymptomatic COVID-19 (p = 0.054) was found. There was no statistically significant difference in the level of thyroid stimulating hormone between the groups. The level of C-reactive protein in women with COVID-19 was naturally higher as compared to the control group (p = 0.009) and the group of asymptomatic patients (p = 0.001). A lower TNF-alpha level was found in the group of patients without clinical signs of COVID-19 as compared to the control group (p = 0.007) and the group with COVID-19 (p = 0.00007). The analysis of correlation relationships revealed a positive correlation between of free T4 and TNF-alpha levels in women with COVID-19 (r = 0.38, p = 0.004).Conclusions. The moderate course of COVID-19 in the post-reproductive women is associated with an increase of free T4 level, which positively correlates with TNF-alpha level. Twelve months after COVID-19, thyroid status in women remains at the level of the acute phase of the disease.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"14 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease\",\"authors\":\"N. Semenova, S. Kolesnikov, E. V. Vyrupaeva, L. Sholokhov, L. V. Rychkova, А. G. Petrova, M. R. Akhmedzyanova, M. Darenskaya, L. Kolesnikova\",\"doi\":\"10.29413/abs.2023-8.2.4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim. To assess the thyroid status and its relationship with tumor necrosis factor alpha (TNF-alpha) in post-reproductive women in the acute phase of the COVID-19 of moderate course and 12 months after the disease.Materials and methods. 85 women aged 45 to 69 years were divided into groups: women without COVID-19, not vaccinated, with no antibodies to COVID-19 (IgG) – control group (n = 15); women in the acute phase of COVID-19 of a moderate course, accompanied by pneumonia – main group (n = 57); patients from the main group who agreed to be examined 12 months after having COVID-19 (n = 14); women with IgG in blood who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19 (n = 13). Using hormone replacement therapy and the presence of thyroid disease in history were the exclusion criteria from the study.Results. 75.4 % of patients with COVID-19 had euthyroidism, 12.3 % had subclinical hyperthyroidism. An increase of free thyroxine (free T4) level in women with COVID-19 as compared to the control group (p = 0.004) and the group with asymptomatic COVID-19 (p = 0.054) was found. There was no statistically significant difference in the level of thyroid stimulating hormone between the groups. The level of C-reactive protein in women with COVID-19 was naturally higher as compared to the control group (p = 0.009) and the group of asymptomatic patients (p = 0.001). A lower TNF-alpha level was found in the group of patients without clinical signs of COVID-19 as compared to the control group (p = 0.007) and the group with COVID-19 (p = 0.00007). The analysis of correlation relationships revealed a positive correlation between of free T4 and TNF-alpha levels in women with COVID-19 (r = 0.38, p = 0.004).Conclusions. The moderate course of COVID-19 in the post-reproductive women is associated with an increase of free T4 level, which positively correlates with TNF-alpha level. Twelve months after COVID-19, thyroid status in women remains at the level of the acute phase of the disease.\",\"PeriodicalId\":32463,\"journal\":{\"name\":\"Acta Biomedica Scientifica\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Biomedica Scientifica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29413/abs.2023-8.2.4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Immunology and Microbiology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Biomedica Scientifica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29413/abs.2023-8.2.4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Immunology and Microbiology","Score":null,"Total":0}

引用次数: 0

摘要

的目标。目的探讨新冠肺炎中度急性期及发病后12个月生殖后妇女甲状腺功能状况及其与肿瘤坏死因子α (tnf - α)的关系。材料和方法。85名年龄在45岁至69岁之间的女性分为两组:未感染COVID-19、未接种疫苗、无COVID-19抗体(IgG)的女性-对照组(n = 15);中度病程的COVID-19急性期妇女，并伴有肺炎-主要组(n = 57);主要组患者同意在感染COVID-19 12个月后接受检查(n = 14);血液中含有IgG的妇女在过去12个月内否认有任何COVID-19症状-无症状COVID-19 (n = 13)。使用激素替代疗法和既往有甲状腺疾病是排除标准。75.4%的患者有甲状腺功能亢进，12.3%的患者有亚临床甲状腺功能亢进。与对照组(p = 0.004)和无症状组(p = 0.054)相比，COVID-19女性游离甲状腺素(游离T4)水平升高。两组间促甲状腺激素水平差异无统计学意义。与对照组(p = 0.009)和无症状患者组(p = 0.001)相比，COVID-19女性的c反应蛋白水平自然更高。与对照组(p = 0.007)和COVID-19患者组(p = 0.00007)相比，无临床症状患者组的tnf - α水平较低。相关性分析显示，COVID-19女性游离T4与tnf - α水平呈正相关(r = 0.38, p = 0.004)。生殖期后妇女COVID-19病程中度与游离T4水平升高相关，游离T4水平与tnf - α水平呈正相关。在COVID-19发生12个月后，妇女的甲状腺状况仍处于该疾病急性期的水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease

The aim. To assess the thyroid status and its relationship with tumor necrosis factor alpha (TNF-alpha) in post-reproductive women in the acute phase of the COVID-19 of moderate course and 12 months after the disease.Materials and methods. 85 women aged 45 to 69 years were divided into groups: women without COVID-19, not vaccinated, with no antibodies to COVID-19 (IgG) – control group (n = 15); women in the acute phase of COVID-19 of a moderate course, accompanied by pneumonia – main group (n = 57); patients from the main group who agreed to be examined 12 months after having COVID-19 (n = 14); women with IgG in blood who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19 (n = 13). Using hormone replacement therapy and the presence of thyroid disease in history were the exclusion criteria from the study.Results. 75.4 % of patients with COVID-19 had euthyroidism, 12.3 % had subclinical hyperthyroidism. An increase of free thyroxine (free T4) level in women with COVID-19 as compared to the control group (p = 0.004) and the group with asymptomatic COVID-19 (p = 0.054) was found. There was no statistically significant difference in the level of thyroid stimulating hormone between the groups. The level of C-reactive protein in women with COVID-19 was naturally higher as compared to the control group (p = 0.009) and the group of asymptomatic patients (p = 0.001). A lower TNF-alpha level was found in the group of patients without clinical signs of COVID-19 as compared to the control group (p = 0.007) and the group with COVID-19 (p = 0.00007). The analysis of correlation relationships revealed a positive correlation between of free T4 and TNF-alpha levels in women with COVID-19 (r = 0.38, p = 0.004).Conclusions. The moderate course of COVID-19 in the post-reproductive women is associated with an increase of free T4 level, which positively correlates with TNF-alpha level. Twelve months after COVID-19, thyroid status in women remains at the level of the acute phase of the disease.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊