P. Sanders, G. Moulin, C. Gaudiche, B. Delepine, D. Mourot
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Comparison of automated liquid chromatographic and bioassay methods for determining spiramycin concentration in bovine plasma.
The performance of a liquid chromatographic (LC) method for spiramycin measurement in bovine plasma has been compared with that of a microbiological method. Plasma samples were obtained from cattle administered spiramycin intravenously. Comparison tests used were intraclass correlation (r1), correlation (r), and Student's paired t-test. For concentrations lower than 2.5 IU/mL, microbiological values were higher than LC values. This difference in results modified pharmacokinetic interpretation and might be explained by the presence of microbiologically active metabolites.
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