Osama A. O. Elhag, Huang Xiaojing, Z. Weiying, Xiong Li, Yuan Yongze, Deng Lingfeng, L. Deli, Liu Yingle, Geng Hui
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Notice of RetractionEctopic Expression of Tim-3 Induces Tumor-Specific Antitumor Immunity
Although T-cell immunoglobulin-and mucin-domain containing molecule 3 (Tim-3) was originally identified as a negatively immunoregulator, the role of Tim-3 in regulating immune response is not fully understand. In this study, we report the finding that intratumor injection of pTim-3, a eukaryotic expression plasmid which expresses murine Tim-3 molecule, potently inhibited tumor growth and results in prolonged survival. These results gain further insight into the function of Tim-3 expressed on nonlymphoid tissues in regulating antitumor immune response.
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