甘油三酯种子可溶性膳食纤维部分对奥氮平诱导大鼠代谢综合征的预防作用

A. Kushwah, K. Saini, G. Gupta
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引用次数: 0

摘要

生长foenum graecum TF属于家庭蝶形花科已经从古代传统上用作香料和人种药理药促进消化和减少糖尿病病人血糖水平在印度在目前的研究中可溶性膳食纤维自卫队隔绝TF种子和调查的角色自卫队TF对奥氮平引起的代谢并发症引起的代谢综合征是口服OLZ毫克公斤老鼠几天然后老鼠治疗和OLZ SDFF TF的毫克公斤po和二甲双胍作为标准毫克公斤po天自卫队TF治疗显著降低身体体重增加饲料和水摄入血糖口服葡萄糖耐量试验OGTT血脂肝酶抗氧化剂尿酸和改善血流动力学参数状态,减少组织病理学变化引起的OLZ治疗大鼠自卫队TF增加饱腹感的抑制食欲,改善葡萄糖和脂质代谢和抗氧化潜能在奥氮平诱导的代谢综合征中发挥有益作用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Soluble dietary fiber fraction of Trigonella foenum graecum seeds prevent olanzapine induced metabolic syndrome in rats
Trigonella foenum graecum TF belongs to the family Fabaceae it has been from ancient time used as a spice and traditionally ethno pharmacological medicine for promoting digestion and reduce blood sugar levels in a diabetic patient in India In the present study soluble dietary fiber SDF was isolated from TF seeds and investigates the role of SDF of TF against olanzapine induced metabolic complications Metabolic syndrome was induced by oral administration of OLZ mg kg in rats for days Then rats were treated with OLZ and SDFF of TF at and mg kg po day and metformin as a standard mg kg po day SDF of TF treatment significantly decreased body weight gain feed and water intake blood glucose oral glucose tolerance test OGTT lipid profile liver enzymes uric acid and improved hemodynamic parameters antioxidant status and reduced histopathological changes caused by OLZ treatment in rats SDF of TF increased the satiety suppresses appetite and improved the glucose and lipid metabolism and antioxidant potential exert the beneficial role in olanzapine induced metabolic syndrome
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