乳腺癌放疗患者淋巴结受累及相关危险因素:一项针对15000名女性的20年研究

Pub Date : 2021-06-04 DOI:10.15296/ijwhr.2021.39

Fariborz Rousta, M. Dadashzadeh, F. Mahdavi, A. Nasseri

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引用次数: 0

摘要

目的:肿瘤大小和腋窝淋巴结(LN)累及作为预后指标和选择辅助治疗的指导。本研究旨在评估乳腺癌(BC)放疗患者LN受累及相关危险因素。材料和方法:采用普查抽样方法，2000-2020年在大不里士医科大学进行的回顾性描述性研究纳入了15,000名转诊接受放疗的BC女性。记录LN累及相关危险因素，采用t检验和方差分析，P<0.05为显著性水平。结果:本研究中LN累及的患病率为25%。雌激素受体状态和淋巴结受累与转移有关。雌激素受体阴性患者发生转移的优势比约为雌激素受体阳性患者的两倍。最后，有LN累及的患者发生转移的风险是没有LN累及的患者的8倍。结论:一般来说，雌激素受体状态和淋巴结受累与BC患者的转移有关。因此，这些因素可以被视为在高危患者中早期开始必要干预的指南。

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Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women

Objectives: Tumor size and axillary lymph node (LN) involvement are used as prognostic markers and a guide for choosing adjuvant therapy. This study aimed to evaluate LN involvement and related risk factors in patients with breast cancer (BC) referred for radiotherapy. Materials and Methods: Using the census sampling method, 15,000 women with BC referring for radiotherapy were enrolled in this retrospective descriptive study performed at Tabriz University of Medical Sciences during 2000-2020. LN involvement and related risk factors were recorded and analyzed using the t test and ANOVA test at a significance level of P<0.05. Results: The prevalence of LN involvement in this study was 25%. The estrogen receptor status and LN involvement were associated with metastasis. The odds ratio of metastasis in patients with a negative estrogen receptor was about twice that of women with estrogen receptor positivity. Finally, the risk of metastasis in patients presenting with LN involvement was eight times higher than that of patients without LN involvement. Conclusion: In general, estrogen receptor status and LN involvement were associated with metastasis in patients with BC. Thus, these factors can be regarded as a guide to start necessary interventions earlier in at-risk patients.

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