化疗引起的打嗝(CIH)的危险因素

Ryuichiro Hosoya, Ippei Tanaka, R. Ishii‐Nozawa, T. Amino, T. Kamata, Seiichi Hino, H. Kagaya, Y. Uesawa
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引用次数: 3

摘要

背景:打嗝是常见的药物副作用。我们之前对打嗝的临床危险因素的分析确定化疗是一个与打嗝风险相关的因素。因此,在本研究中,我们研究了与化疗相关的打嗝的危险因素。方法:纳入2014年4月至2014年12月在武藏野红十字医院接受肿瘤化疗并住院的所有患者。我们调查了患者的人口统计学、身体特征和其他临床因素,以确定化疗引起的打嗝(CIH)的危险因素。我们通过单因素和多因素分析比较了CIH组和非CIH组,并确定了CIH的危险因素。结果:292例患者中有48例出现打嗝,发生率为16.4%。单因素分析显示,男性、疼痛、恶心和呕吐与CIH有关。顺铂、培美曲塞、吉西他滨、依托泊苷、地塞米松、甲氧氯普胺与CIH相关。发现与顺铂、培美曲塞、吉西他滨和依托泊苷剂量相关。多变量分析确定男性性别(OR, 72.69;95% CI, 6.95 - 757.64),恶心和呕吐(OR, 52.01;95% CI, 3.93 - 447.13),地塞米松(OR, 4.55;95% CI, 1.12 - 16.91),顺铂(OR, 3.84;95% CI, 1.52 - 9.70)和依托泊苷(OR, 3.72;95% CI, 1.14 - 12.11)作为打嗝的独立危险因素。结论:本研究首次报道了CIH发生的危险因素。我们的研究结果表明,男性、恶心、地塞米松、顺铂和依托泊苷等药物是CIH的重要危险因素。这些结果可能有助于阐明潜在的机制和指导治疗,以减少打嗝的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk Factors for Cancer Chemotherapy-Induced Hiccups (CIH)
Background: Hiccups are common somatic side effects of medication. Our previous analysis of the clinical risk factors for hiccups identified chemotherapy as a factor related to hiccup risk. Therefore, in the present study, we investigated the risk factors for hiccups associated with chemotherapy. Methods: We included all patients who received cancer chemotherapy and were hospitalized at the Musashino Red Cross Hospital between April 2014 and December 2014. We investigated patient demographics, physical characteristics, and other clinical factors to identify the risk factors for chemotherapy-induced hiccups (CIH). We conducted univariate and multivariable analysis to compare the CIH group and the non-CIH and determined risk factors of CIH. Results: Hiccups were identified in 48 of 292 patients with an incidence rate of 16.4%. Univariate analysis revealed that the male gender, pain, and nausea and vomiting were related to CIH. It also showed that cisplatin, pemetrexed, gemcitabine, etoposide, dexamethasone, and metoclopramide were related to CIH.A correlation which was found with doses of cisplatin, pemetrexed, gemcitabine, and etoposide. Multivariable analysis identified male gender (OR, 72.69; 95% CI, 6.95 - 757.64), nausea and vomiting (OR, 52.01; 95% CI, 3.93 - 447.13), dexamethasone (OR, 4.55; 95% CI, 1.12 - 16.91), cisplatin (OR, 3.84; 95% CI, 1.52 - 9.70), and etoposide (OR, 3.72; 95% CI, 1.14 - 12.11) as independent risk factors for hiccups. Conclusions: The present study is the first one to report risk factors for the development of CIH. Our results suggest that male gender, having nausea, and the drugs dexamethasone, cisplatin, and etoposide are important risk factors for CIH. These results may assist in elucidation of the underlying mechanisms and guide therapy to reduce hiccup risk.
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