{"title":"支撑液膜法提取头孢菌素C","authors":"A.C. Ghosh, S. Borthakur, M.K. Roy, N.N. Dutta","doi":"10.1016/0956-9618(95)00114-L","DOIUrl":null,"url":null,"abstract":"<div><p>As a step towards development of an efficient method for separation of cephalosporin C from fermentation broth, reactive extraction in supported liquid membrane has been investigated using simulated feed solution. Experiments were conducted in a diaphragm type cell with Celgard-2400 membrane as the solid support and Aliquat-336 as the carrier dissolved in butyl acetate as the diluent. Cephalosporin C was permeated across the membrane from an alkaline feed phase of carbonate buffer into an acidic strip solution of acetate buffer via a coupled transport phenomenon involving Cl ions. The permeation process was analyzed from the hypothesis of an overall transport dependance on diffusion across the liquid membrane and total re-extracting in the stripping phase.</p></div>","PeriodicalId":101160,"journal":{"name":"Separations Technology","volume":"5 2","pages":"Pages 121-126"},"PeriodicalIF":0.0000,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0956-9618(95)00114-L","citationCount":"22","resultStr":"{\"title\":\"Extraction of cephalosporin C using supported liquid membrane\",\"authors\":\"A.C. Ghosh, S. Borthakur, M.K. Roy, N.N. Dutta\",\"doi\":\"10.1016/0956-9618(95)00114-L\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>As a step towards development of an efficient method for separation of cephalosporin C from fermentation broth, reactive extraction in supported liquid membrane has been investigated using simulated feed solution. Experiments were conducted in a diaphragm type cell with Celgard-2400 membrane as the solid support and Aliquat-336 as the carrier dissolved in butyl acetate as the diluent. Cephalosporin C was permeated across the membrane from an alkaline feed phase of carbonate buffer into an acidic strip solution of acetate buffer via a coupled transport phenomenon involving Cl ions. The permeation process was analyzed from the hypothesis of an overall transport dependance on diffusion across the liquid membrane and total re-extracting in the stripping phase.</p></div>\",\"PeriodicalId\":101160,\"journal\":{\"name\":\"Separations Technology\",\"volume\":\"5 2\",\"pages\":\"Pages 121-126\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0956-9618(95)00114-L\",\"citationCount\":\"22\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Separations Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/095696189500114L\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separations Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/095696189500114L","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Extraction of cephalosporin C using supported liquid membrane
As a step towards development of an efficient method for separation of cephalosporin C from fermentation broth, reactive extraction in supported liquid membrane has been investigated using simulated feed solution. Experiments were conducted in a diaphragm type cell with Celgard-2400 membrane as the solid support and Aliquat-336 as the carrier dissolved in butyl acetate as the diluent. Cephalosporin C was permeated across the membrane from an alkaline feed phase of carbonate buffer into an acidic strip solution of acetate buffer via a coupled transport phenomenon involving Cl ions. The permeation process was analyzed from the hypothesis of an overall transport dependance on diffusion across the liquid membrane and total re-extracting in the stripping phase.
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