THE RATIO OF THE STATE OF LOCAL AND IMMUNE REACTIONS IN SAMI WOMEN

THE RATIO OF THE STATE OF LOCAL AND IMMUNE REACTIONS IN SAMI WOMEN Samodova A.V., Dobrodeeva L.K., Balashova S.N., Pashinskaya K.O. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Arkhangelsk Introduction: One of the most important issues in the field of biology is to identify the features of interaction and correlation of local and systemic immune responses. There is some information about the role of defects of local immune protection in the formation of systemic immune reactions. A big problem is created by cases of the development of a systemic inflammatory response syndrome, which is often associated with a deficiency of immune responses in the area of distress. Objective: To determine the ratio of the state of local and immune reactions in Sami women. Methods: 49 practically healthy Sami women aged 21 to 44 years living in Lovozero village of Murmansk region were examined. The comparison group consisted of 50 practically healthy women of the Arkhangelsk region of the same age range. The hemogram, phagocytic activity of peripheral venous blood neutrophils, the content of lymphocyte phenotypes (CD3+, CD4+, CD8+, CD10+, CD95+) by indirect immunoperoxidase reaction and flow cytometry, the concentration of IgM, IgG, IgA by enzyme immunoassay, circulating immune complexes by precipitation were studied. The composition and quantity of microflora, cytogram, phagocytic activity of neutrophils, sorption capacity of epithelial cells, the content of sIgA and CEC IgG were studied in the separated mucous membranes of the pharynx, intestines and urine. The results are presented as the arithmetic mean and the error of the mean (Mm). For comparison between groups, an independent sample t-test or a nonparametric Mann-Whitney U-test was used, depending on the distribution. Results: It was found that the immune status of Sami women is characterized by the usual activation of cell-mediated cytotoxicity mechanisms in the northern territories, a deficiency of phagocyte activity and the accumulation of CEC, but these features are more pronounced in them. A decrease in the frequency of neutropenia registration does not compensate for the deficiency of phagocytic protection, but increases the secretory activity of neutrophils. The secretory activity of leukocytes is associated with their higher migration capacity into the mucous membranes, which does not compensate for the low activity of local phagocytes, the sorption capacity of epithelial cells and sIgA. A feature of the Sami immune reactivity is higher concentrations of IgA and IgM against a background of low IgG content. Conclusion: The migration activity of leukocytes is initiated by preventive reactions in places of distress and begins with reactions of hemodynamic changes. Perhaps, therefore, the concentration of granulocytes and lymphocytes in the Sami blood is higher due to cells with cytolytic activity.