骨组织缺血性坏死:定义、流行病学、类型、危险因素、发病机制。文献分析综述

V. Bialik, M. Makarov, E. Byalik, S. Makarov, A. Karateev, V. Nesterenko, A. A. Chernikova, D. V. Kapitonov, A. I. Gorelova
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引用次数: 0

摘要

骨组织的缺血性坏死(AN)是一种常见的病理,影响任何年龄的人,更常见的是年轻人和健全的人。这种疾病导致软骨下骨的快速破坏和塌陷,随后是受影响关节的继发性骨关节炎(OA)的发展。这篇综述文章的目的是介绍有关AN的患病率,最常见的影响关节,危险因素和疾病的发病机制的积累知识。由于世界上大多数文献来源都是关于构成AN发病机制的单个部分和事实的知识,本文分析了所有已知的疾病发展路径,从缺血开始到衰竭和继发性OA的发展,并按时间顺序介绍了发病机制。根据本文的结果,提出了AN一词的定义,并在发病机制内确定了疾病的阶段,确定了最有希望的保守治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Avascular necrosis of bone tissue: Definition, epidemiology, types, risk factors, pathogenesis of the disease. Analytical review of the literature
Avascular necrosis (AN) of bone tissue is a common pathology that affects people of any age, more often young and able-bodied. The disease leads to rapid destruction of the subchondral bone and collapse, followed by the development of secondary osteoarthritis (OA) of the affected joint.The purpose of this review article is to present the accumulated knowledge about the prevalence of AN, the most commonly affected joints, risk factors and pathogenesis of the disease. Since most of the world’s literature sources present knowledge about the individual parts and facts that make up the pathogenesis of AN, this article analyzes all known paths of the development of the disease from the onset of ischemia to collapse and the development of secondary OA and the pathogenesis is presented in chronological order. Based on the results of the article, a definition of the term AN was proposed, and the stages of the disease within the pathogenesis, the most promising for conservative methods of treatment, were identified.
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