分子改变了人们对皮肤治疗的看法

L.Ya. Fedorich
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引用次数: 0

摘要

目的:研究维生素A衍生物的现代分类、作用机制和临床疗效,分析类维甲酸在表皮和真皮层面具有普遍作用机制的局部治疗各种皮肤病的疗效。材料和方法。本文综述了基于第一代天然类维甲酸维甲酸(维甲酸)的药物的文献和国际临床试验结果分析。本文分析了20世纪80年代至今数十位作家的作品。大多数来源提供了痤疮治疗局部类维生素a的结果的详细信息,这是临床指南的基础。近几十年来对维甲酸基制剂进行的长期(6个月以上)研究发现,维甲酸在治疗皮肤光老化、光化性角化病等方面具有独特的临床效果。它们是由于类维生素a对角质形成细胞和成纤维细胞的核受体的影响而实现的。结果和讨论。维甲酸的分子作用机制,实现了研究最多的类维甲酸的细胞和组织的影响,被系统化和分组在一个单一的综述。已经证明,维甲酸的一个独特特征是它能够直接激活皮肤细胞的所有RARs亚型,并间接激活RARs核受体。介绍了一种新型外用现代药物AltrenoТМ,该洗剂含有0.05%微细维甲酸、透明质酸钠、可溶性胶原蛋白和甘油。这种组合在痤疮治疗中表现出预期的临床疗效,并防止副作用,如干燥,发红和去角质。AltrenoТМ被批准用于9岁及以上的儿童。结论。维甲酸(维甲酸)是一种现代强大的类维甲酸具有普遍的作用机制,推荐用于治疗痤疮。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecule which changed the view on skin treatment
Objective — to study the modern classification, mechanisms of action and clinical effects of vitamin A derivatives, to analyze retinoid for local treatment of various dermatoses with a universal mechanism of action at the epidermis and dermis levels. Materials and methods. A review of the literature and an analysis of the results of international clinical trials of drugs based on the natural retinoid of the first generation — tretinoin (retinoic acid) is presented. The works of dozens of authors since 1980s to the present day are analyzed. Most sources provide detailed information on the results of topical retinoids in acne therapy, which are the base of clinical guidelines. Long-term (6 months or more) studies of retinoic acid-based preparations carried out in recent decades have discovered the unique clinical effects of tretinoin in the treatment of skin photoaging, actinic keratosis, etc. They are achieved due to the effect of tretinoid on the nuclear receptors of keratinocytes and fibroblasts. Results and discussion. The molecular mechanisms of action of retinoic acid, realizing the cellular and tissue effects of the most studied retinoid, are systematized and grouped in a single review. It has been proven that a unique feature of tretinin is its ability to activate directly all subtypes of RARs- and, indirectly, RARs-nuclear receptors of skin cells. A new modern drug for external use is presented — AltrenoТМ lotion containing micronized 0.05 % tretinoin in combination with sodium hyaluronate, soluble collagen and glycerin. This combination exhibits the expected clinical efficacy in acne therapy and prevents side effects such as dryness, redness and exfoliation. AltrenoТМ is approved for use in children of 9 years of age and older. Conclusions. Tretinoin (retinoic acid) is a modern powerful retinoid with a universal mechanism of action, recommended for the treatment of acne.
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