顽固性视神经和视网膜浸润在急性淋巴细胞白血病复发中的作用

IF 0.8 Q4 CLINICAL NEUROLOGY

Neuro-Ophthalmology Pub Date : 2021-06-11 DOI:10.1080/01658107.2021.1933079

Corrina P. Azarcon, G. V. Mercado, R. N. Alfonso

{"title":"顽固性视神经和视网膜浸润在急性淋巴细胞白血病复发中的作用","authors":"Corrina P. Azarcon, G. V. Mercado, R. N. Alfonso","doi":"10.1080/01658107.2021.1933079","DOIUrl":null,"url":null,"abstract":"ABSTRACT Isolated ocular relapse of leukaemia is rare. We present the case of a 20-year-old male with T-cell acute lymphoblastic leukaemia (ALL) who reported sudden blurring of vision in both eyes 6 months after documentation of ALL remission. Ocular examination showed bilateral infiltrative optic neuropathies and serous retinal detachments. Cerebrospinal fluid and bone marrow samples were negative for blast cells. Systemic work-up did not reveal any other sites of involvement. The ocular infiltration partially responded to reinduction chemotherapy, intraconal steroids, and radiotherapy. This report demonstrates a challenging case of isolated ocular ALL relapse presenting as bilateral optic nerve and retinal infiltration.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"180 1","pages":"126 - 130"},"PeriodicalIF":0.8000,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recalcitrant Optic Nerve and Retinal Infiltration in a Relapse of Acute Lymphoblastic Leukaemia\",\"authors\":\"Corrina P. Azarcon, G. V. Mercado, R. N. Alfonso\",\"doi\":\"10.1080/01658107.2021.1933079\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT Isolated ocular relapse of leukaemia is rare. We present the case of a 20-year-old male with T-cell acute lymphoblastic leukaemia (ALL) who reported sudden blurring of vision in both eyes 6 months after documentation of ALL remission. Ocular examination showed bilateral infiltrative optic neuropathies and serous retinal detachments. Cerebrospinal fluid and bone marrow samples were negative for blast cells. Systemic work-up did not reveal any other sites of involvement. The ocular infiltration partially responded to reinduction chemotherapy, intraconal steroids, and radiotherapy. This report demonstrates a challenging case of isolated ocular ALL relapse presenting as bilateral optic nerve and retinal infiltration.\",\"PeriodicalId\":19257,\"journal\":{\"name\":\"Neuro-Ophthalmology\",\"volume\":\"180 1\",\"pages\":\"126 - 130\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2021-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuro-Ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/01658107.2021.1933079\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuro-Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/01658107.2021.1933079","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

孤立性眼部白血病复发是罕见的。我们报告了一个20岁的男性患有t细胞急性淋巴细胞白血病(ALL)的病例，他在ALL缓解后6个月报告双眼突然视力模糊。眼部检查显示双侧浸润性视神经病变和浆液性视网膜脱离。脑脊液和骨髓样本未见胚细胞。系统的检查没有发现任何其他涉及的部位。眼部浸润对再诱导化疗、囊内类固醇和放疗有部分反应。本报告报告了一例具有挑战性的孤立性眼部ALL复发，表现为双侧视神经和视网膜浸润。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recalcitrant Optic Nerve and Retinal Infiltration in a Relapse of Acute Lymphoblastic Leukaemia

ABSTRACT Isolated ocular relapse of leukaemia is rare. We present the case of a 20-year-old male with T-cell acute lymphoblastic leukaemia (ALL) who reported sudden blurring of vision in both eyes 6 months after documentation of ALL remission. Ocular examination showed bilateral infiltrative optic neuropathies and serous retinal detachments. Cerebrospinal fluid and bone marrow samples were negative for blast cells. Systemic work-up did not reveal any other sites of involvement. The ocular infiltration partially responded to reinduction chemotherapy, intraconal steroids, and radiotherapy. This report demonstrates a challenging case of isolated ocular ALL relapse presenting as bilateral optic nerve and retinal infiltration.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neuro-Ophthalmology 医学-临床神经学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neuro-Ophthalmology publishes original papers on diagnostic methods in neuro-ophthalmology such as perimetry, neuro-imaging and electro-physiology; on the visual system such as the retina, ocular motor system and the pupil; on neuro-ophthalmic aspects of the orbit; and on related fields such as migraine and ocular manifestations of neurological diseases.