人2q32染色体ΨHSP40加工假基因的鉴定

DNA Sequence Pub Date : 2001-01-01 DOI:10.3109/10425170109025006

M. Hata, K. Kagotani, K. Okumura, M. Seto, K. Ohtsuka

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引用次数: 0

摘要

人类Hsp40基因的假基因已被鉴定(ΨHSP40)。假基因序列在核苷酸水平上与人类Hsp40 mRNA有90%的相似性。在与人类Hsp40 cDNA对应的区域未发现内含子，在同一区域两侧有两个直接重复序列。由于这些特征，伪基因可以被归类为加工伪基因。ΨHSP40通过原位杂交被分配到染色体2q32上。这是首次报道的DnaJ (Hsp40)家族蛋白基因的假基因。

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Characterization of a Processed Pseudogene of Human ΨHSP40 on Chromosome 2q32

A pseudogene for the human Hsp40 gene has been characterized (ΨHSP40). The pseudogene sequence shows 90% similarity to the human Hsp40 mRNA at the nucleotide level. No introns were found in the region corresponding to the human Hsp40 cDNA, and two direct repeats flank this same region. Because of these features, the pseudogene can be classified as a processed pseudogene. ΨHSP40 was assigned to chromosome 2q32 by in situ hybridization. This is the first report of a pseudogene for a member of the DnaJ (Hsp40) family protein gene.

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DNA Sequence

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