{"title":"脑室周围结节性异位:发病机制、癫痫发生及其对高级脑功能的影响。","authors":"Valmir Passarelli, Camila Hobi Moreira","doi":"10.14800/MCE.20","DOIUrl":null,"url":null,"abstract":"Periventricular nodular heterotopias (PNH) is a neuronal migration disorder characterized by nodules of gray matter located along the lateral ventricles, which can range from isolated single nodules to bilateral confluent nodules. This malformation of cortical development can be related genetic or extrinsic factors. Reading dysfluency, epilepsy and normal intelligence are main hallmark. PNH and overlying cortex integrate a (dis)functional network. In this review, we discuss the recent progress about pathogenes and epileptogenesis on PNH, and their participation in the processing of higher cortical functions.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"28 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2014-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Periventricular Nodular Heterotopia: Pathogenesis, Epileptogenesis and Implications in Higher Cerebral Functions.\",\"authors\":\"Valmir Passarelli, Camila Hobi Moreira\",\"doi\":\"10.14800/MCE.20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Periventricular nodular heterotopias (PNH) is a neuronal migration disorder characterized by nodules of gray matter located along the lateral ventricles, which can range from isolated single nodules to bilateral confluent nodules. This malformation of cortical development can be related genetic or extrinsic factors. Reading dysfluency, epilepsy and normal intelligence are main hallmark. PNH and overlying cortex integrate a (dis)functional network. In this review, we discuss the recent progress about pathogenes and epileptogenesis on PNH, and their participation in the processing of higher cortical functions.\",\"PeriodicalId\":18603,\"journal\":{\"name\":\"Molecular & Cellular Epilepsy\",\"volume\":\"28 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & Cellular Epilepsy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14800/MCE.20\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & Cellular Epilepsy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/MCE.20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Periventricular Nodular Heterotopia: Pathogenesis, Epileptogenesis and Implications in Higher Cerebral Functions.
Periventricular nodular heterotopias (PNH) is a neuronal migration disorder characterized by nodules of gray matter located along the lateral ventricles, which can range from isolated single nodules to bilateral confluent nodules. This malformation of cortical development can be related genetic or extrinsic factors. Reading dysfluency, epilepsy and normal intelligence are main hallmark. PNH and overlying cortex integrate a (dis)functional network. In this review, we discuss the recent progress about pathogenes and epileptogenesis on PNH, and their participation in the processing of higher cortical functions.
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