纳米氧化铈的制备及其抗氧化性能

Karthi Kandhasamy, K. Premkumar
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引用次数: 0

摘要

近年来,纳米颗粒(NPs)的研究和实际应用都有了显著的增长。由于纳米颗粒具有广泛的显著生物效应,包括抗菌和抗氧化特性,许多生物医学应用都取得了成功。无害的纳米颗粒作为一种有前途的新型抗氧化剂正受到越来越多的关注。氧化铈是一种镧系稀土元素。氧化铈纳米粒子(CNPs)具有较大的比表面积和良好的催化活性,是Ce3+和Ce4+双重氧化态的结果,具有良好的抗菌和抗氧化活性。利用紫外可见分光光度计、扫描电子显微镜、x射线衍射、ζ电位、傅里叶变换红外光谱和动态光散射等分析技术对CNPs进行了表征。CNPs对金黄色葡萄球菌(15mm)和大肠杆菌(14mm)表现出较强的抑制区。采用DPPH和ABTS技术研究了CNPs的体外抗氧化活性,分别在47.61µg/mL和49.26µg/mL浓度下观察到其50%的自由基清除能力。因此,我们的研究报告了CNPS可以作为一种突出的高效抗氧化剂和抗菌剂。然而,需要进一步的研究来了解毒性评估的可能机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication of Cerium Oxide Nanoparticles with Improved Antibacterial Potential and Antioxidant Activity
Recent years have seen a dramatic uptick in both research into and practical application of nanoparticles (NPs). Many biomedical applications have found success with the use of nanoparticles due to their wide spectrum of significant biological effects, including antibacterial and antioxidant properties. Nanoparticles that aren't harmful are gaining traction as a promising new class of antioxidants. Cerium oxide is a lanthanide rare-earth element. Cerium oxide nanoparticles (CNPs) exhibit a large surface area and good catalytic activity, the result of the dual oxidation state of CNPs, Ce3+ and Ce4+, has good antibacterial and antioxidant activity. CNPs were characterised by using analytical techniques such as the UVVisible spectrophotometer, scanning electron microscopy, X-ray diffraction, zeta potential, Fourier transform infrared spectroscopy, and dynamic light scattering (DLS). CNPs exhibited a strong zone of inhibition against S. aureus (15mm) and E. coli (14mm). In vitro antioxidant activity of CNPs was investigated using the DPPH and ABTS techniques, with 50% of their radical scavenging potential being observed at concentrations of 47.61µg/mL and 49.26µg/mL respectively. Thus, our study reports that CNPS could be used as a prominent and efficient antioxidant and antibacterial agent. However, further studies are needed to understand the possible mechanisms of toxicity assessment.
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