Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant

Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction.