{"title":"口服大马哈鱼头蛋白酶水解物及其血管紧张素i转换酶抑制肽的降压作用","authors":"Tomoki Ohta, A. Iwashita, S. Sasaki, Y. Kawamura","doi":"10.3136/FSTI9596T9798.3.339","DOIUrl":null,"url":null,"abstract":"The antihypertensive action of protease hydrolysates derived from chum salmon head was investigated by oral administration to spontaneously hypertensive rats (SHR), and the angiotensin I-converting enzyme (ACE) [EC 3.4.15.1] inhibitory peptides were isolated from them. Hydrolysates by Biopurase SP-10 showed the highest ACE inhibitory activity in vitro. The systolic blood pressure of SHR treated with the hydrolysates orally decreased from 200.6±5.0 to 177.2±9.9 (0.05<p<0.1) 24 h after administration. From the hydrolysates, two peptides having ACE inhibitory activity were isolated. Their amino acid sequence was Gly-Ile-Gly and Asp-Trp and had the IC50 values of 730 μM and 13 μM, respectively. Asp-Trp was one of the strongest ACE inhibitory dipeptides ever reported in food protein hydrolysates.","PeriodicalId":12457,"journal":{"name":"Food Science and Technology International, Tokyo","volume":"1 1","pages":"339-343"},"PeriodicalIF":0.0000,"publicationDate":"1997-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"23","resultStr":"{\"title\":\"Antihypertensive Action of the Orally Administered Protease Hydrolysates of Chum Salmon Head and Their Angiotensin I-Converting Enzyme Inhibitory Peptides\",\"authors\":\"Tomoki Ohta, A. Iwashita, S. Sasaki, Y. Kawamura\",\"doi\":\"10.3136/FSTI9596T9798.3.339\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antihypertensive action of protease hydrolysates derived from chum salmon head was investigated by oral administration to spontaneously hypertensive rats (SHR), and the angiotensin I-converting enzyme (ACE) [EC 3.4.15.1] inhibitory peptides were isolated from them. Hydrolysates by Biopurase SP-10 showed the highest ACE inhibitory activity in vitro. The systolic blood pressure of SHR treated with the hydrolysates orally decreased from 200.6±5.0 to 177.2±9.9 (0.05<p<0.1) 24 h after administration. From the hydrolysates, two peptides having ACE inhibitory activity were isolated. Their amino acid sequence was Gly-Ile-Gly and Asp-Trp and had the IC50 values of 730 μM and 13 μM, respectively. Asp-Trp was one of the strongest ACE inhibitory dipeptides ever reported in food protein hydrolysates.\",\"PeriodicalId\":12457,\"journal\":{\"name\":\"Food Science and Technology International, Tokyo\",\"volume\":\"1 1\",\"pages\":\"339-343\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"23\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Technology International, Tokyo\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3136/FSTI9596T9798.3.339\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Technology International, Tokyo","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3136/FSTI9596T9798.3.339","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antihypertensive Action of the Orally Administered Protease Hydrolysates of Chum Salmon Head and Their Angiotensin I-Converting Enzyme Inhibitory Peptides
The antihypertensive action of protease hydrolysates derived from chum salmon head was investigated by oral administration to spontaneously hypertensive rats (SHR), and the angiotensin I-converting enzyme (ACE) [EC 3.4.15.1] inhibitory peptides were isolated from them. Hydrolysates by Biopurase SP-10 showed the highest ACE inhibitory activity in vitro. The systolic blood pressure of SHR treated with the hydrolysates orally decreased from 200.6±5.0 to 177.2±9.9 (0.05
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