新型融合苊酰基嘧啶杂化物的合成及其光物理性质和HSA相互作用

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-05-04 DOI:10.1080/10610278.2021.1975710

Ergin Yalçın

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引用次数: 0

摘要

摘要描述了一种简便、通用的合成新型功能化10-(1h -吲哚-3-基)苊[1,2-d]嘧啶-8-胺(化合物4)的方法。利用红外光谱、核磁共振和质谱对化合物3和嘧啶衍生物4进行了表征，并用光度和荧光滴定法研究了化合物4的光物理性质及其与人血清白蛋白的相互作用。化合物4在加入HSA后表现出荧光增强和最大次色移，这种相互作用是由分子对接支持的。总的来说，化合物4对HSA具有很好的亲和力，这在以前的任何融合阿那芬酮-嘧啶杂化类似物中都没有报道。图形抽象

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Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interaction

ABSTRACT A facile and versatile procedure for the synthesis of novel functionalised 10-(1H-indol-3-yl)acenaphtho[1,2-d]pyrimidin-8-amine (compound 4) has been described. The novel intermediate enone (3) and pyrimidine derivatives (4) were characterised by using FT-IR, NMR and MS. Moreover, the photophysical properties of compound 4 and its interaction with HSA (Human Serum Albumin) have been investigated by means of photometric and fluorimetric titration. Compound 4 showed the increase in fluorescence and hypsochromic shift of its maximum upon the addition of HSA that interaction is supported by molecular docking. Overall, Compound 4 has promising affinity towards HSA which was not previously reported for any fused acenaphtenone–pyrimidine hybrid analogues. Graphical abstract

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.