人类古基因组学的伦理指导:新的和正在进行的观点。

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY
Raquel E. Fleskes, A. Bader, K. Tsosie, Jennifer K. Wagner, Katrina G. Claw, N. Garrison
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引用次数: 9

摘要

在过去的二十年里,对祖先人类古代基因组的研究,或人类古基因组研究,在规模和范围上都迅速扩大。伦理话语随后出现,以解决社会责任和科学稳健进行研究的问题。在这里,我们重点介绍了针对古基因组研究人员的职业道德指导的主要来源。我们描述了现有指导方针之间的紧张关系,同时解决了核心问题,如同意、破坏性研究方法、数据访问和管理。目前,关注科学成果的指导方针与让科学家对利益相关者社区(如后代)负责的指导方针之间存在不协调。因此,我们提供了额外的工具来导航古代DNA研究的复杂性,同时在科学过程中集中与利益相关者社区的接触。预计《基因组学与人类遗传学年度评论》第23卷的最终在线出版日期为2022年10月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ethical Guidance in Human Paleogenomics: New and Ongoing Perspectives.
Over the past two decades, the study of ancient genomes from Ancestral humans, or human paleogenomic research, has expanded rapidly in both scale and scope. Ethical discourse has subsequently emerged to address issues of social responsibility and scientific robusticity in conducting research. Here, we highlight and contextualize the primary sources of professional ethical guidance aimed at paleogenomic researchers. We describe the tension among existing guidelines, while addressing core issues such as consent, destructive research methods, and data access and management. Currently, there is a dissonance between guidelines that focus on scientific outcomes and those that hold scientists accountable to stakeholder communities, such as descendants. Thus, we provide additional tools to navigate the complexities of ancient DNA research while centering engagement with stakeholder communities in the scientific process. Expected final online publication date for the Annual Review of Genomics and Human Genetics, Volume 23 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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